Description
(-)-Epicatechin gallate (ECG) is a flavanol/catechin originally found in Camilla and other plan sources; it exhibits antioxidative, neuromodulatory, anticancer, and anti-inflammatory activities. ECG displays agonist activity at cannabinoid 1 (CB1) receptors. ECG also inhibits expression of FLT3 and decreases phosphorylation of p38 MAPK, Akt, and STAT5 in acute myelogenous leukemia (AML) cells, suppressing cell proliferation. In vitro, this compound inhibits LPS- or peptidoglycan-induced production of VEGF and expression of COX-2.