• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
10,11-Dehydrocurvularin

10,11-Dehydrocurvularin

Product ID D170310
Cas No. 1095588-70-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $115.90 In stock
5 mg $388.40 In stock
10 mg $674.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

10,11-Dehydrocurvularin is a fungal metabolite produced by Penicillium species. 10,11-Dehydrocurvularin is a cyclic lactone that has been shown to interfere with NF-kB, JAK/STAT, and TGF-beta signalling. Furthermore, this macrocyclic polyketide has been found to be an activator of heat shock response and to produce immune-modulating activities.

Product Info

Cas No.

1095588-70-7

Purity

≥98%

Formula

C16H18O5

Formula Wt.

290.32

Chemical Name

Dehydrocurvularin

IUPAC Name

(5S,9E)-13,15-dihydroxy-5-methyl-4-oxabicyclo[10.4.0]hexadeca-1(12),9,13,15-tetraene-3,11-dione  

Synonym

α,β-Dehydrocurvularin; Dehydrocurvularin; Trans-Dehydrocurvularin; AC1O5P3Y 

Melting Point

220-223°C

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D170310 MSDS PDF

Info Sheet

D170310 Info Sheet PDF

References

Ha TM, Ko W, Lee SJ, et al. Anti-inflammatory effects of curvularin-type metabolites form a marine-derived fungal strain Penicillium sp. SF-5859 in lipopolysaccharide-induced RAW264.7 macrophages. Mar Drugs. 2017 Sep 2;15(9):pii:E282. PMID: 28869509.

Schreiber D, Marx L, Felix S, et al. Anti-inflammatory effects of fungal metabolites in mouse intestine as revealed by in vitro models. Front Physiol. 2017 Aug 7;8:566. PMID: 28824460.

de Castro MV, Ioca LP, Williams DE, et al. Condensation of macrocyclic polyketides produced by Penicillium sp. DRF2 with mercaptopyruvate represents a new fungal detoxification pathway. J Nat Prod. 2016 Jun 24;79(6):1668-1678. PMID: 27227682.

Xu Y, Espinosa-Artiles P, Schubert V, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-2047. PMID: 23335766.

Rudolph K, Serwe A, Erkel G. Inhibition of TGF-beta signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclodecindione and galiellalactone. Cytokine, 2013 Jan;61(1):285-296. PMID: 23134667.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V0274

    [Lys8]-Vasopressin

    Peptide, vasopressin analog; V1/2 agonist.

    ≥95%
  • C2948

    Chloroadenosine

    Nucleoside (adenosine) analog; DNA chain termin...

    ≥98%
  • T2933

    4-Thiouridine

    Modified nucleotide used for labeling DNA; DNA ...

    ≥99%
  • L0107

    Lactacystin

    Found in Streptomyces; proteasome inhibitor.

    ≥98%
  • D3353

    Diminazene Aceturate

    Diamidine; ACE2 activator, DNA polymerase inhib...

    ≥98%
  • S3449

    Simvastatin

    Statin; HMG-CoA reductase inhibitor, potential ...

    ≥98%
  • N5605

    Nobiletin

    Polymethoxylated flavone found in citrus fruits...

    ≥97%
  • N5409

    Nocodazole

    Microtubule polymerization inhibitor.

    ≥98%
  • A8812

    AWD 131-138

    GABA-A positive modulator.

    ≥99%
  • C2945

    Chlorophyllin Sodium-Copper Salt

    Semi-synthetic derivative of chlorophyll; food ...

    USP 28
  • C9881

    Cytochalasin D

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • A5285

    [Ile7]-Angiotensin III

    Peptide, derivative of AT III, cleavage product...

    ≥95%
  • I5313

    Indinavir Sulfate

    HIV protease, GLUT4, calpain inhibitor.

    ≥99%
  • G1749

    Gemfibrozil

    Fibrate; PPARα agonist, enoyl-CoA reductase in...

    ≥98%
  • M3577

    Mitiglinide Calcium

    ATP-sensitive K+ channel blocker, potential RyR...

    ≥98%
  • C5782

    Coumarin

    Benzopyrone found in various plants, precursor ...

    ≥98%
  • A6264

    Apramycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • A4777

    Altiratinib

    c-MET, Tie-2, VEGFR inhibitor.

    ≥98%
  • C4517

    Clenbuterol Hydrochloride

    β2-adrenergic agonist.

    ≥98%
  • D3575

    2,5-Di-tert-butyl-4-hydroxyanisole

    BHA derivative; potential Ca2+ ATPase inhibitor...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only