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3-Aminobenzamide

3-Aminobenzamide

Product ID A4931
Cas No. 3544-24-9
Purity ≥97%
Product Unit SizeCostQuantityStock
100 mg $78.50 In stock
250 mg $168.40 In stock
500 mg $224.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

3-Aminobenzamine is an inhibitor of poly(ADP)-ribosyl polymerase (PARP) that exhibits cytoprotective, anti-atherosclerotic, and anticancer activities. 3-Aminobenzamide prevents UV-induced cell death in vitro and inhibits TGF-β1-induced phosphorylation of Smad3 in other cellular models. In vivo, this compound inhibits production of inflammatory cytokines, suppresses PARP activation, and decreases atherosclerotic lesion size. Additionally, 3-aminobenzamide induces G1 phase cell cycle arrest, downregulates expression of cyclin D1, β-catenin, c-Jun, c-Myc, and Id2, upregulates expression of p21 and genes involved in differentiation, and induces differentiation in osteosarcoma cells.

Product Info

Cas No.

3544-24-9

Purity

≥97%

Formula

C7H8N2O

Formula Wt.

136.15

Chemical Name

3-aminobenzamide

IUPAC Name

3-aminobenzamide

Synonym

3-AB, 3-ABA, INO-1001

Melting Point

115-116°C

Solubility

Soluble in DMSO or ethanol.

Appearance

White Fluffy Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A4931 MSDS PDF

Info Sheet

A4931 Info Sheet PDF

Brochures

PARP Inhibitors Flyer

References

Lakatos P, Szabó É, Hegedűs C, et al. 3-Aminobenzamide protects primary human keratinocytes from UV-induced cell death by a poly(ADP-ribosyl)ation independent mechanism. Biochim Biophys Acta. 2013 Mar;1833(3):743-51. PMID: 23246565.

Huang D, Wang Y, Wang L, et al. Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell. PLoS One. 2011;6(10):e27123. PMID: 22073128.

Xie JJ, Yu X, Liao YH, et al. Poly (ADP-Ribose) polymerase inhibition attenuates atherosclerotic plaque development in ApoE-/- mice with hyperhomocysteinemia. J Atheroscler Thromb. 2009 Oct;16(5):641-53. PMID: 19776495.

De Blasio A, Messina C, Santulli A, et al. Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. FEBS Lett. 2005 Jan 31;579(3):615-20. PMID: 15670817.

Custom Order

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