• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
3,3′-Diindolylmethane

3,3′-Diindolylmethane

Product ID D3232
Cas No. 1968-05-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $50.40 In stock
5 g $136.50 In stock
10 g $236.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

3,3’-Diindolylmethane (DIM) is found in cruciferous vegetables; it exhibits anti-inflammatory, immunosuppressive, antioxidative, anti-diabetic, anti-fibrotic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities. DIM acts as an agonist at the aryl hydrocarbon receptor. DIM increases levels of Foxp3 and function of Treg cells and decreases expression of toll-like receptor 4 (TLR4) and Th17 cells, preventing hepatic steatosis and inflammation in vivo. DIM also prevents the development of experimental autoimmune encephalitis (EAE) by suppressing T cell activity. In vivo, this compound decreases glucose levels, insulin levels, and Hb1Ac by increasing activity of glucokinase and glucose-6-phosphate dehydrogenase and decreasing activity of glucose-6-phosphatase and fructose-1,6-bisphosphatase. DIM also prevents the development of liver fibrosis in vivo. In cellular and animal models of nasopharyngeal carcinoma, DIM inhibits cellular invasion and metastasis and tumor growth; it also decreases activity of HDAC2.

Product Info

Cas No.

1968-05-4

Purity

≥98%

Formula

C17H14N2

Formula Wt.

246.31

IUPAC Name

3-(1H-indol-3-ylmethyl)-1H-indole

Synonym

3,3'-Diindolymethane, 3,3'-Methylenebis-1H-indole, DIM

Melting Point

163-165°C

Solubility

Soluble in DMSO (200 mg/mL). Insoluble in water.

Appearance

Off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3232 MSDS PDF

Info Sheet

D3232 Info Sheet PDF

References

Liu Y, She W, Wang F, et al. 3, 3'-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. Int Immunopharmacol. 2014 Oct 1. [Epub ahead of print]. PMID: 25281898.

Rouse M, Rao R, Nagarkatti M, et al. 3,3'-diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through microRNA signaling pathways. J Pharmacol Exp Ther. 2014 Aug;350(2):341-52. PMID: 24898268.

Wu T, Chen C, Li F, et al. 3,3'-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition. Exp Ther Med. 2014 Jun;7(6):1635-1638. PMID: 24926357.

Poornima J, Mirunalini S. Regulation of carbohydrate metabolism by indole-3-carbinol and its metabolite 3,3'-diindolylmethane in high-fat diet-induced C57BL/6J mice. Mol Cell Biochem. 2014 Jan;385(1-2):7-15. PMID: 24072613.

Zhang Z, Gao Z, Hu W, et al. 3,3'-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression. Br J Pharmacol. 2013 Oct;170(3):649-60. PMID: 23902531.

Chen C, Chen SM, Xu B, et al. In vivo and in vitro study on the role of 3,3'-diindolylmethane in treatment and prevention of nasopharyngeal carcinoma. Carcinogenesis. 2013 Aug;34(8):1815-21. PMID: 23568953.

Beaver LM, Yu TW, Sokolowski EI, et al. 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol. 2012 Sep 15;263(3):345-51. PMID: 22800507.

Cho HJ, Seon MR, LLee YM, et al. 3,3’-Diindolylmethane suppresses the inflammatory response to lipopolysacharide in murine macrophages. J Nutr. 2008 Jan;138(1):17-23. PMID: 18156398.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L1761

    Leptomycin B

    Polyketide; CRM1 inhibitor.

    ≥98%
  • N7208

    NSC-74859

    STAT3 inhibitor.

    ≥98%
  • E4416

    Eledoisin

    Peptide, substance P analog; NK agonist.

    ≥95%
  • P0932

    PCI-32765

    BTK and IL-2-inducible kinase inhibitor.

    ≥99%
  • D3351

    4-Dimethylaminopyridine

    Acyl transfer catalyst, involved in peptide syn...

    ≥98%
  • O6932

    Oridonin

    Diterpenoid found in Rabdosia rubescens; potent...

    ≥98%
  • L0360

    Lapatinib Ditosylate Monohydrate

    EGFR inhibitor.

    ≥99%
  • T174441

    Telacebec

    Anti-tuberculosis

    ≥98%
  • A971336

    Azilsartan Medoxomil

    Prodrug

    ≥98%
  • A5278

    Angiotensin III, human

    Endogenous peptide, cleavage product of AT II; ...

    ≥95%
  • H9763

    Hypoxanthine

    Endogenous purine derivative of xanthine.

    ≥98%
  • B030966

    BAY 11-7082

    inhibits inflammatory signaling

    ≥98%
  • E7657

    Etoposide

    Podophyllotoxin derivative; topoisomerase II in...

    ≥98%
  • L1628

    Ac-LEHD-pNa

    Caspase 9 substrate.

    ≥95%
  • P3561

    Piperlongumine

    Found in Piper longum; TxA2 antagonist, ubiquit...

    ≥98%
  • B011458

    Baloxavir

    Cap-dependent endonuclease inhibitor

    ≥ 99%
  • M1677

    11-Methoxyyangonin

    Minor kavalactone originally found in Piper met...

    ≥98%
  • B8144

    Bulleyaconitine A

    Found in Aconitum bulleyanum; voltage-gated Na+...

    ≥95%
  • N3278

    7-Nitroindazole

    nNOS inhibitor.

    ≥98%
  • P3597

    Pizotyline Malate

    5-HT1A partial agonist, 5-HT2C antagonist.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only