Description
4’-Demethylepipodophyllotoxin is a topoisomerase II inhibitor found in Podophyllum. Derivatives of this compound exhibit anticancer chemotherapeutic activity.
Product Unit Size | Cost | Quantity | Stock |
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4’-Demethylepipodophyllotoxin is a topoisomerase II inhibitor found in Podophyllum. Derivatives of this compound exhibit anticancer chemotherapeutic activity.
Cas No. | 6559-91-7 |
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Purity | ≥98% |
Formula | C21H20O8 |
Formula Wt. | 400.38 |
Chemical Name | Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5- dimethoxyphenyl)-, (5R-(5-alpha,5a-beta,8a-alpha,9-beta))- |
IUPAC Name | (5S,5aR,8aR,9R)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a, 9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one |
Melting Point | 246-248°C |
Appearance | White Cystal Powder |
Store Temp | -20°C |
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Ship Temp | Ambient |
MSDS | |
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Info Sheet |
Xiao L, Zhao W, Li HM, et al. Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways. Eur J Med Chem. 2014 Jun 10;80:267-77. PMID: 24793877.
Yang TM, Guo SF, Chen CR, et al. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4'-demethylepipodophyllotoxin ether. J Pharm Pharmacol. 2008 Feb;60(2):179-88. PMID: 18237465.
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