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5,6-Dehydrokawain is a kavalactone originally found in Piper methysticum (kava plant) and Alpinia that exhibits neuroprotective and antithrombotic activities. 5,6-Dehydrokawain inhibits aggregation and ATP release of platelets as well as formation of thromboxane B2 (TxB2). Additionally, this compound prevents H2O2-induced toxicity, decreasing release of lactate dehydrogenase, activation of caspase 3, and oxidative stress in neurons.
| Cas No. | 1952-41-6 |
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| Purity | ≥98% |
| Formula | C14H12O3 |
| Formula Wt. | 228.25 |
| IUPAC Name | 4-methoxy-6-[(E)-2-phenylethenyl]pyran-2-one |
| Melting Point | 138-140°C |
| Appearance | White/ Off White Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Rao YK, Shih HN, Lee YC, et al. Purification of kavalactones from Alpinia zerumbet and their protective actions against hydrogen peroxide-induced cytotoxicity in PC12 cells. J Biosci Bioeng. 2014 Jun 11. [Epub ahead of print]. PMID: 24929995.
Teng CM, Hsu SY, Lin CH, et al. Antiplatelet action of dehydrokawain derivatives isolated from Alpinia speciosa rhizoma. Chin J Physiol. 1990;33(1):41-8. PMID: 2376215.