• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
6-Thioguanine

6-Thioguanine

Product ID T2835
Cas No. 154-42-7
Purity ≥90%
Product Unit SizeCostQuantityStock
250 mg $79.10 In stock
500 mg $126.50 In stock
1 g $197.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

6-Thioguanine is a nucleotide analog of guanine that exhibits anticancer chemotherapeutic, immunosuppressive, and anti-parasitic activities. 6-Thioguanine is incorporated into DNA, altering stability of the topoisomerase II-DNA cleavage complex and increasing DNA fragmentation; these actions result in growth arrest and inhibition of proliferation across many cancer cell lines. In acute lymphoblastic leukemia (ALL) cells, 6-thioguanine increases mitochondrial dysfunction and generation of ROS, inducing a cytotoxic effect. In other in vitro models, 6-thioguanine decreases expression of TNF-related apoptosis-inducing ligand (TRAIL). Additionally, this compound inhibits growth of Toxoplasma gondii.

Product Info

Cas No.

154-42-7

Purity

≥90%

Formula

C5H5N5S

Formula Wt.

167.19

IUPAC Name

2-amino-3,7-dihydropurine-6-thione

Synonym

tioguanine, thioguanine

Melting Point

>360C

Solubility

Soluble in NaOH (50 mg/ml), slightly soluble in ethanol, insoluble in water

Appearance

Off-white to yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T2835 MSDS PDF

Info Sheet

T2835 Info Sheet PDF

References

Zhang F, Fu L, Wang Y. 6-thioguanine induces mitochondrial dysfunction and oxidative DNA damage in acute lymphoblastic leukemia cells. Mol Cell Proteomics. 2013 Dec;12(12):3803-11. PMID: 24043426.

Bohon J, de los Santos CR. Effect of 6-thioguanine on the stability of duplex DNA. Nucleic Acids Res. 2005 May 19;33(9):2880-6. PMID: 15905476.

Thomas CW, Myhre GM, Tschumper R, et al. Selective inhibition of inflammatory gene expression in activated T lymphocytes: a mechanism of immune suppression by thiopurines. J Pharmacol Exp Ther. 2005 Feb;312(2):537-45. PMID: 15388785.

Pfefferkorn ER, Bzik DJ, Honsinger CP. Toxoplasma gondii: mechanism of the parasitostatic action of 6-thioxanthine. Exp Parasitol. 2001 Dec;99(4):235-43. PMID: 11888251.

Morgan CJ, Chawdry RN, Smith AR, et al. 6-Thioguanine-induced growth arrest in 6-mercaptopurine-resistant human leukemia cells. Cancer Res. 1994 Oct 15;54(20):5387-93. PMID: 7923170.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S584780

    Sotorasib racemate

    KRAS inhibitor

    ≥99%
  • N1721

    Nefiracetam

    Pyrrolidone; NMDA and mGluR5 agonist, N-type an...

    ≥98%
  • P0370

    Paromomycin Sulfate

    Aminoglycoside; protein translation inhibitor, ...

    ≥98%
  • P0219

    Paeonol

    Found in Paeonia, Arisaema, Dioscorea; MAO-A/B ...

    ≥98%
  • G5322

    GNF-5

    Abl inhibitor.

    ≥99%
  • C0271

    Carfilzomib

    Epoxomicin analog; proteasome inhibitor.

    ≥98%
  • P200637

    PF-04745637

    TRPA1 antagonist

    ≥98%
  • C0367

    S-(−)-Carbidopa Monohydrate

    Hydrazine; L-amino acid decarboxylase inhibitor...

    ≥98%
  • I7870

    Itraconazole

    Triazole; 14-α demethylase inhibitor, Smo modu...

    ≥98%
  • C0140

    Calcitonin, eel

    Endogenous neuropeptide hormone, lowers extrace...

    ≥95%
  • H9863

    Hyperforin Dicyclohexylammonium

    Stable salt form of hyperforin, a compound foun...

    ≥97%
  • R0349

    Ramosetron

    5-HT3 antagonist.

    ≥99%
  • V014451

    Valiltramiprosate

    beta-Amyloid anti-oligomer and aggregation inhi...

    ≥99%
  • G2873

    Growth Hormone Releasing Factor, sheep

    Endogenous peptide hormone, involved in growth ...

    ≥95%
  • T3585

    Tivozanib

    VEGFR1/2/3, c-Kit, PDGFR inhibitor.

    ≥98%
  • A9818

    Azelastine Hydrochloride

    TRPV1 agonist, histamine H1 antagonist.

    ≥98%
  • T5609

    β-Tocotrienol

    Antioxidant, vitamin E derivative found in vege...

    ≥98%
  • E7230

    Ethambutol Dihydrochloride

    Arabinosyl transferase inhibitor.

    ≥98%
  • D0025

    DAMGO

    Synthetic peptice; μOR agonist.

    ≥95%
  • H9711

    (Z)-4-Hydroxytamoxifen

    SERM.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only