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8-Gingerol

8-Gingerol

Product ID G3253
Cas No. 23513-08-8
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $142.80 In stock
5 mg $264.40 In stock
25 mg $884.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

8-Gingerol is originally found in species of Zingiber; it exhibits antiemetic, anti-diabetic, anticancer, immunosuppressive, antioxidative, anti-inflammatory, cardiomodulatory, and anti-asthma activities. 8-Gingerol inhibits 5-HT3 receptors and also attenuates airway hyperresponsiveness in animal models. 8-Gingerol also increases glucose uptake and upregulates expression of GLUT4 in vitro. This compound inhibits ConA-, LPS-, and OVA-stimulated spleenocyte proliferation and decreases levels of CD19+ B cells, CD3+ T cells, and IgG in vivo. Additionally, 8-gingerol increases radical scavenging of superoxide and hydroxyl radicals, inhibits oxidative burst activity, and decreases expression of NO and PGE2 in vitro. In animal models, 8-gingerol displays positive inotropic activity, increasing longitudinal contractions, decreasing peak tension and relaxation times, and increasing sarcoplasmic Ca2+ uptake. This compound also inhibits proliferation of breast adenocarcinoma cells.

Product Info

Cas No.

23513-08-8

Purity

≥99%

Formula

C19H30O4

Formula Wt.

322.44

IUPAC Name

(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)dodecan-3-one

Solubility

1mg/ml in methanol

Appearance

Off white-tan waxy solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G3253 MSDS PDF

Info Sheet

G3253 Info Sheet PDF

References

Townsend EA, Siviski ME, Zhang Y, et al. Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation. Am J Respir Cell Mol Biol. 2013 Feb;48(2):157-63. PMID: 23065130.

Li Y, Tran VH, Duke CC, et al. Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubes. Planta Med. 2012 Sep;78(14):1549-55. PMID: 22828920.

Almada da Silva J, Becceneri AB, Sanches Mutti H, et al. Purification and differential biological effects of ginger-derived substances on normal and tumor cell lines. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:157-62. PMID: 22858304.

Lu J, Guan S, Shen X, et al. Immunosuppressive activity of 8-gingerol on immune responses in mice. Molecules. 2011 Mar 22;16(3):2636-45. PMID: 21441866.

Dugasani S, Pichika MR, Nadarajah VD, et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol. 2010 Feb 3;127(2):515-20. PMID: 19833188.

Abdel-Aziz H, Windeck T, Ploch M, et al. Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. Eur J Pharmacol. 2006 Jan 13;530(1-2):136-43. PMID: 16364290.

Kobayashi M, Ishida Y, Shoji N, et al. Cardiotonic action of [8]-gingerol, an activator of the Ca++-pumping adenosine triphosphatase of sarcoplasmic reticulum, in guinea pig atrial muscle. J Pharmacol Exp Ther. 1988 Aug;246(2):667-73. PMID: 2457078.

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