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Abemaciclib

Abemaciclib

Product ID A044176
Cas No. 1231929-97-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $97.70 In stock
25 mg $217.90 In stock
100 mg $601.00 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Abemaciclib is a CDK4 and CDK6 inhibitor found to inhibit retinoblastoma phosphorylation, leading to G1/S arrest in ER+ breast cancer cells and to promote metabolic alterations in metastatic HR+ breast cancer cells.

Product Info

Cas No.

1231929-97-7

Purity

≥98%

Formula

C27H32F2N8

Formula Wt.

506.61

Chemical Name

N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

IUPAC Name

N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine

Synonym

LY2835219

Solubility

10 mM in DMSO; Soluble in dilute Acidic solution. Insoluble in Water

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A044176 MSDS PDF

Info Sheet

A044176 Info Sheet PDF

References

Torres-Guzman R, Calsina B, Hermoso A, et al. Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. Oncotarget. 2017 May 10. Epub ahead of print. PMID: 28537883

Tate SC, Burke TF, Hartman D, et al. Optimising the combination dosing strategy of abemaciclib and vemurafenib in BRAF-mutated melanoma xenograft tumours. Br J Cancer. 2016 Mar 15;114(6):669-679. PMID: 26978007

Knudsen ES, Hutcheson J, Vail P, et al. Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jun 10. Epub ahead of print. PMID: 28620137

Custom Order

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