Description
AG-18 is a tyrphostin that inhibits EGFR and PDGFR; it also blocks Ca2+ currents in vascular smooth muscle. AG-18 suppresses clathrin-mediated endocytosis and is often used to study that process.
AG-18 is a tyrphostin that inhibits EGFR and PDGFR; it also blocks Ca2+ currents in vascular smooth muscle. AG-18 suppresses clathrin-mediated endocytosis and is often used to study that process.
Cas No. | 118409-57-7 |
---|---|
Purity | ≥98% |
Formula | C10H6N2O2 |
Formula Wt. | 186.17 |
IUPAC Name | (3,4-Dihydroxybenzylidene)malononitrile |
Synonym | Tyrphostin A23 |
Solubility | DMSO 37 mg/mL Ethanol 37 mg/mL Water Insoluble |
Appearance | Yellow solid |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Montezano AC, Callera GE, Yogi A, et al. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1511-8. PMID: 18467645.
Yaish P, Gazit A, Gilon C, et al. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science. 1988 Nov 11;242(4880):933-5. PMID: 3263702.
Thienopyridine; P2Y12 antagonist.
5-HT1B/1D agonist.
Essential vitamin (B2) found in vegetables, dai...
Synthetic peptide hormone, PTH analog; PTH1R ag...
Impurity of omeprazole
Endogenous cardiomodulatory peptide; NPR-B agon...
α7 and β4 nAChR agonist, α4β2 and α6β2 nA...
Triterpene sapogenin found in species of Panax;...
Indole derivative found in Isatis, Calanthe, an...
Endogenous APP peptide cleavage product, primar...
NMDA NR1/NR2B antagonist.
Neuropeptide found in Locusta migratoria.
β2-adrenergic agonist.
Phallotoxin found in Amanita phalloides; microt...
Caffeic acid derivative.
Cyclic sesquiterpene found in ginger root; pote...
Endogenous peptide hormone, involved in feeding...
Organosulfur found in garlic.
Diterpene found in coffee beans.
Endogenous peptide hormone, GLP-1 fragment, inv...