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AG-18

AG-18

Product ID A2401
Cas No. 118409-57-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $59.30 In stock
25 mg $228.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AG-18 is a tyrphostin that inhibits EGFR and PDGFR; it also blocks Ca2+ currents in vascular smooth muscle. AG-18 suppresses clathrin-mediated endocytosis and is often used to study that process.

Product Info

Cas No.

118409-57-7

Purity

≥98%

Formula

C10H6N2O2

Formula Wt.

186.17

IUPAC Name

(3,4-Dihydroxybenzylidene)malononitrile

Synonym

Tyrphostin A23

Solubility

DMSO 37 mg/mL Ethanol 37 mg/mL Water Insoluble

Appearance

Yellow solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A2401 MSDS PDF

Info Sheet

A2401 Info Sheet PDF

References

Montezano AC, Callera GE, Yogi A, et al. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1511-8. PMID: 18467645.

Yaish P, Gazit A, Gilon C, et al. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science. 1988 Nov 11;242(4880):933-5. PMID: 3263702.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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