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AICAR

AICAR

Product ID A3208
Cas No. 2627-69-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $47.30 In stock
50 mg $165.50 Please Inquire
100 mg $283.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

5-Aminoimidazole-4 -carboxamide-1-β-D-ribofuranoside (AICAR) is an activator of AMPK that also decreases mTORC1 signaling; it displays anticancer, antihypertensive, anti-diabetic, and anti-inflammatory activities. AICAR enhances the efficacy of rapamycin in several cancer cells and suppresses signaling by HER2 and EGFR2 in breast cancer cells. This compound also decreases mean arterial pressure in ApoE-/- animal models and induces vasodilation in aortic rings. In animal models of insulin resistance, AICAR decreases hyperglycemia, lowers insulin levels, and improves insulin signaling. Additionally, AICAR inhibits LPS/D-Gal-induced upregulation of TNF-α, NO, and myeloperoxidase in animal models of hepatitis.

Product Info

Cas No.

2627-69-2

Purity

≥98%

Formula

C9H14N4O5

Formula Wt.

258.23

Chemical Name

5-Amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide

IUPAC Name

5-Amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide

Synonym

5-aminoimidazole-4 -carboxamide-1-β-D-ribofuranoside

Solubility

Soluble in water (9 mg/ml), DMSO or dimethyl formamid

Appearance

Off-white solid.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A3208 MSDS PDF

Info Sheet

A3208 Info Sheet PDF

References

Mukhopadhyay S, Chatterjee A, Kogan D, et al. 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells. Cell Cycle. 2015 Aug 31:0. [Epub ahead of print]. PMID: 26323019.

Greig FH, Ewart MA, McNaughton E, et al. The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice. Vascul Pharmacol. 2015 Jul 18. [Epub ahead of print]. PMID: 26196300.

Niederberger E, King TS, Russe OQ, et al. Activation of AMPK and its Impact on Exercise Capacity. Sports Med. 2015 Jul 18. [Epub ahead of print]. PMID: 26186961.

Radika MK, Anuradha CV. Activation of insulin signaling and energy sensing network by AICAR, an AMPK activator in insulin resistant rat tissues. J Basic Clin Physiol Pharmacol. 2015 Jun 27. [Epub ahead of print]. PMID: 26124049.

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