Description
Altretamine is an anticancer chemotherapeutic agent that binds DNA at guanine and cytosine residues, forming DNA adducts. This alkylating agent is also metabolized to formaldehyde. Altretamine is clinically used to treat ovarian cancer.
Product Unit Size | Cost | Quantity | Stock |
---|
Altretamine is an anticancer chemotherapeutic agent that binds DNA at guanine and cytosine residues, forming DNA adducts. This alkylating agent is also metabolized to formaldehyde. Altretamine is clinically used to treat ovarian cancer.
Cas No. | 645-05-6 |
---|---|
Purity | ≥98% |
Formula | C9H18N6 |
Formula Wt. | 210.28 |
Chemical Name | N,N,N',N',N'',N''-Hexamethyl-1,3,5-triazine-2,4,6-triamine |
IUPAC Name | 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine |
Synonym | HMM, Hexalen, Hexamethylmelamine |
Melting Point | 172-174°C |
Solubility | Practically insoluble in water. Soluble in DMSO. |
Appearance | White Crystal Powder |
Store Temp | 4°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Chan JK, Loizzi V, Manetta A, et al. Oral altretamine used as salvage therapy in recurrent ovarian cancer. Gynecol Oncol. 2004 Jan;92(1):368-71. PMID: 14751188.
Coley HM, Brooks N, Phillips DH, et al. The role of the N-(hydroxymethyl)melamines as antitumour agents: mechanism of action studies. Biochem Pharmacol. 1995 May 11;49(9):1203-12. PMID: 7763301.
Hansen LA, Hughes TE. Altretamine. DICP. 1991 Feb;25(2):146-52. PMID: 1905441.
Thienylbutyl ITC analog.
Benzylpiperidine; AMPA potentiator.
NSAID; COX-1/2 inhibitor.
Imidazoline and α2-adrenergic agonist, Nav1.7 ...
Mast cell destabilizer; potential TRP antagonis...
Diphenylmethane derivative, stimulates colonic ...
Fungal metabolite produced by Penicillium speci...
Triterpene saponin found in species of Panax.
STING inhibitor
Mycotoxin produced by Penicillum and Aspergillu...
Immunomodulator; teratogen.
HEXIM1 activator.
β-lactam cephalosporin; penicillin binding pro...
G-quadruplex ligand; DNA breakage inducer.
α2-adrenergic and imidazoline-1 antagonist, AT...
NSAID; GABA-A potentiator, COX-1/2 inhibitor.
5-HT1A agonist, D2, 5-HT1D antagonist.
Arp2/3 inhibitor.
PKC and PKG inhibitor.
Fluoroquinolone; topoisomerase IV and bacterial...