Description
AM630 is a CB2 receptor antagonist. It is selective for CB2 over the CB1 receptor. AM630 activates TRPA1 in sensory neurons. This activation increases the hyperalgesic effect from capsaicin-induced pain models.
Product Unit Size | Cost | Quantity | Stock |
---|
AM630 is a CB2 receptor antagonist. It is selective for CB2 over the CB1 receptor. AM630 activates TRPA1 in sensory neurons. This activation increases the hyperalgesic effect from capsaicin-induced pain models.
Cas No. | 164178-33-0 |
---|---|
Purity | ≥97% |
Formula | C23H25IN2O3 |
Formula Wt. | 504.37 |
Chemical Name | 6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone |
IUPAC Name | [6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone |
Synonym | AM 630, Iodopravadoline |
Solubility | 100mM in DMSO |
Appearance | White to off-white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Ross RA, Brockie HC, Stevenson LA, et al. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br J Pharmacol. 1999 Feb;126(3):665-72. PMID: 10188977
Patil M, Patwardhan A, Salas MM, et al. Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons. Neuropharmacology, 2011 Sep;61(4):778-88. PMID: 21645531.
Indirect activator of STING signaling
Abl, PDGFR, EphR, Src, k-Kit, FYN, LCK, HCK inh...
Triterpene saponin found in Panax.
CRM1/XPO1 inhibitor.
Geldanamycin derivative; HSP90 inhibitor.
Endogenous opioid peptide; δOR and μOR agonis...
Immunomodulator; teratogen.
Tropane alkaloid found in plants in the Solanac...
Long-chain 3-ketoacyl-CoA thiolase inhibitor, p...
Synthetic ITC, erucin analog.
Fluoroquinolone; topoisomerase IV and bacterial...
Endogenous peptide hormone, involved in cell gr...
Kawain derivative, lactone found in Piper methy...
Nitrosourea, DNA alkylator.
Thio sulforaphane analog, ITC.
RyR agonist, SIRT, telomerase, P2Y, GPCR inhibi...
EGFR2 inhibitor.
PP2A activator, Sphk1 and PKC inhibitor.
Endogenous sphingolipid involved in cell signal...
Folate source co-administered with methotrexate...