Description
AM630 is a CB2 receptor antagonist. It is selective for CB2 over the CB1 receptor. AM630 activates TRPA1 in sensory neurons. This activation increases the hyperalgesic effect from capsaicin-induced pain models.
| Product Unit Size | Cost | Quantity | Stock |
|---|
AM630 is a CB2 receptor antagonist. It is selective for CB2 over the CB1 receptor. AM630 activates TRPA1 in sensory neurons. This activation increases the hyperalgesic effect from capsaicin-induced pain models.
| Cas No. | 164178-33-0 |
|---|---|
| Purity | ≥97% |
| Formula | C23H25IN2O3 |
| Formula Wt. | 504.37 |
| Chemical Name | 6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone |
| IUPAC Name | [6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone |
| Synonym | AM 630, Iodopravadoline |
| Solubility | 100mM in DMSO |
| Appearance | White to off-white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Ross RA, Brockie HC, Stevenson LA, et al. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br J Pharmacol. 1999 Feb;126(3):665-72. PMID: 10188977
Patil M, Patwardhan A, Salas MM, et al. Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons. Neuropharmacology, 2011 Sep;61(4):778-88. PMID: 21645531.
ACE inhibitor.
β-adrenergic antagonist.
Oxidative phosphorylation inhibitor.
G-quadruplex ligand; DNA breakage inducer.
Phallotoxin found in Amanita phalloides; microt...
Sulforaphane homolog, ITC found in cruciferous ...
PI3K inhibitor.
Steroid lactone produced by Withania somnifera;...
Xanthine derivative; PDE inhibitor.
Selective inhibitor of LRRK2.
ROCK1/2 inhibitor.
ITC, radical scavenger.
Polyether cationic ionophore.
Neuroprotective flavonoid
Polyphenol found in Gossypium; calcineurin and ...
α-glucosidase inhibitor, potential GLP-1 agoni...
Peptide, involved in paracrine and autocrine ce...
Synthetic ITC, erysolin analog.
5-HT1A and σ1/2 agonist, 5-HT2A/2C/6/7, D1-4, ...
CDK inhibitor, L-type Ca2+ channel blocker.