Description
Amikacin is an aminoglycoside antibiotic that exhibits antibacterial efficacy against gram negative bacteria. Amikacin binds the 30S ribosomal subunit, preventing translation.
Product Unit Size | Cost | Quantity | Stock |
---|
Amikacin is an aminoglycoside antibiotic that exhibits antibacterial efficacy against gram negative bacteria. Amikacin binds the 30S ribosomal subunit, preventing translation.
Cas No. | 39831-55-5 |
---|---|
Purity | ≥98% |
Formula | C22H43N5O13 • 2H2SO4 |
Formula Wt. | 781.76 |
Chemical Name | O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1->6)-O- [6-amino-6-deoxy-α-D-glucopyranosyl-(1->4)]-N1- [(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D- streptamine sulfate |
IUPAC Name | (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3, 5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S, 6R)-6-(aminomethyl)-3,4, 5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide; sulfuric acid |
Synonym | Amikacin sulfate, Amikin, Biklin, Lukadin, Mikavir, Novamin, Pierami |
Melting Point | 220-230°C(dec.) |
Solubility | Soluble in water (50mg/mL). Insolulble in acetone and water. DMSO <1 mg/mL. |
Appearance | White or Almost White Powder |
Store Temp | Ambient |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Barza M, Scheife RT. Drug therapy reviews: Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics--part 4: aminoglycosides. Am J Hosp Pharm. 1977 Jul;34(7):723-37. PMID: 407790.
Kawaguchi H. Discovery, chemistry, and activity of amikacin. J Infect Dis. 1976 Nov;134 SUPPL:S242-8. PMID: 825583.
King P, Citron DM, Griffith DC, et al. Effect of oxygen limitation on the in vitro activity of levofloxacin and other antibiotics administered by the aerosol route against Pseudomonas aeruginosa from cystic fibrosis patients. Diagn Microbiol Infect Dis. 2010 Feb;66(2):181-186. PMID: 19828274.
α7 and β4 nAChR agonist, α4β2 and α6β2 nA...
Long-chain 3-ketoacyl-CoA thiolase inhibitor, p...
Prenylflavinoid, derivative of xanthohumol foun...
Derivative of methyl caffeate, hydroxycinnamic ...
Synthetic peptide, stimulates gastric acid secr...
Alkyl sulfonate; DNA alkylator.
Endogenous glycosaminoglycan that is produced b...
Triterpene saponin found in Panax.
Endogenous peptide hormone derived from POMC, i...
Endogenous bile acid; FXR agonist.
Cyclosporin metabolite; weak calmodulin inhibit...
Protease substrate.
Cembranoid diterpene found in Sarcophyton glauc...
ITC, sulforaphane analog.
Diphenylmethane, inhibits secretion of cortisol...
Triterpene saponin found in species of Panax. <...
Arginine source used to increase NO production....
FGFR inhibitor.
AT-II antagonist, PPARγ/δ modulator.
Endogenous peptide hormone involved in feeding ...