Description
Amikacin is an aminoglycoside antibiotic that exhibits antibacterial efficacy against gram negative bacteria. Amikacin binds the 30S ribosomal subunit, preventing translation.
| Product Unit Size | Cost | Quantity | Stock |
|---|
Amikacin is an aminoglycoside antibiotic that exhibits antibacterial efficacy against gram negative bacteria. Amikacin binds the 30S ribosomal subunit, preventing translation.
| Cas No. | 39831-55-5 |
|---|---|
| Purity | ≥98% |
| Formula | C22H43N5O13 • 2H2SO4 |
| Formula Wt. | 781.76 |
| Chemical Name | O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1->6)-O- [6-amino-6-deoxy-α-D-glucopyranosyl-(1->4)]-N1- [(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D- streptamine sulfate |
| IUPAC Name | (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3, 5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S, 6R)-6-(aminomethyl)-3,4, 5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide; sulfuric acid |
| Synonym | Amikacin sulfate, Amikin, Biklin, Lukadin, Mikavir, Novamin, Pierami |
| Melting Point | 220-230°C(dec.) |
| Solubility | Soluble in water (50mg/mL). Insolulble in acetone and water. DMSO <1 mg/mL. |
| Appearance | White or Almost White Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Barza M, Scheife RT. Drug therapy reviews: Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics--part 4: aminoglycosides. Am J Hosp Pharm. 1977 Jul;34(7):723-37. PMID: 407790.
Kawaguchi H. Discovery, chemistry, and activity of amikacin. J Infect Dis. 1976 Nov;134 SUPPL:S242-8. PMID: 825583.
King P, Citron DM, Griffith DC, et al. Effect of oxygen limitation on the in vitro activity of levofloxacin and other antibiotics administered by the aerosol route against Pseudomonas aeruginosa from cystic fibrosis patients. Diagn Microbiol Infect Dis. 2010 Feb;66(2):181-186. PMID: 19828274.
ITC found in cruciferous vegetables; AhR antago...
Recombinant HIV glycoprotein antigen fragment.<...
Akt inhibitor.
Polymethoxy flavonoid found in citrus fruits.
β-lactam; penicillin binding protein inhibitor...
Rifampicin derivative; DNA-dependent RNA polyme...
Neuroactive mycotoxin produced by Penicillum an...
Caffeic acid ester found in Melissa, Salvia, an...
Benzopyrone found in various plants, precursor ...
Dual RAF/EGFR inhibitor.
Renin inhibitor.
c-MET, Tie-2, VEGFR inhibitor.
Indirubin derivative.
ACE inhibitor.
Phenyl hydrazide; neuronal oxidative stress inh...
Glutamine analog; γ-glutamyl transferase, CTP ...
Dual kinase and GTPase inhibitor.
DNA alkylator.
Zinc chelator
Cyclosporin metabolite; weak calmodulin inhibit...