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Angiogenin is a small protein that exhibits pro-angiogenic activity. Angiogenin stimulates development of new blood vessels and cleaves RNA similarly to RNase enzymes. Angiogenin binds actin on endothelial cells, increasing protease production and degrading basement membrane connective tissues to allow cell migration and invasion.
| Cas No. | 97950-81-7 |
|---|---|
| Purity | ≥98% |
| Formula Wt. | 14.4 kDa |
| Synonym | Angiogenic factor (human adenocarcinoma HT-29) |
| Solubility | Soluble in water. |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| Info Sheet |
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Gao X, Xu Z. Mechanisms of action of angiogenin. Acta Biochim Biophys Sin (Shanghai). 2008 Jul;40(7):619-24. PMID: 18604453.
Tello-Montoliu A, Patel JV, Lip GY. Angiogenin: a review of the pathophysiology and potential clinical applications. J Thromb Haemost. 2006 Sep;4(9):1864-74. PMID: 16961595.
Leland PA, Staniszewski KE, Park C, et al. The ribonucleolytic activity of angiogenin. Biochemistry. 2002 Jan 29;41(4):1343-50. PMID: 11802736.