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Arformoterol Tartrate

Arformoterol Tartrate

Product ID A6922
Cas No. 200815-49-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $112.60 In stock
10 mg $188.00 In stock
25 mg $338.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Arformoterol is the R,R enantiomer of formoterol. Arformoterol exhibits anti-inflammatory and anti-asthma activities, potentiating the effects of co-administered glucocorticoids in the treatment of asthma and chronic obstructive pulmonary disorder (COPD). Arformoterol activates β2-adrenergic receptors and bitter taste receptors (TAS2Rs) in bronchi, inducing airway relaxation through β2 adrenergic receptor downstream signaling effects on intracellular cAMP and Ca2+ levels. Additionally, arformoterol’s activation of TAS2Rs is thought to involve inhibition of PI3K signaling. Arformoterol inhibits migration of human airway smooth muscle cells through other β2 adrenergic receptor downstream signaling effects on PKA and vasodilator-stimulated phosphoprotein (VASP). In vitro, arformoterol inhibits phosphorylation of JNK, p38 MAPK, and the glucocorticoid receptor.

Product Info

Cas No.

200815-49-2

Purity

≥98%

Formula

C19H24N2O4 • C4H6O6

Formula Wt.

494.19

IUPAC Name

(2R,3R)-2,3-dihydroxybutanedioic acid;N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan- 2-yl]amino]ethyl]phenyl]formamide

Appearance

Yellowish to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A6922 MSDS PDF

Info Sheet

A6922 Info Sheet PDF

References

Grassin-Delyle S, Abrial C, Fayad-Kobeissi S, et al. The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res. 2013 Nov 22;14:134. PMID: 24266887.

Goncharova EA, Goncharov DA, Zhao H, et al. β2-adrenergic receptor agonists modulate human airway smooth muscle cell migration via vasodilator-stimulated phosphoprotein. Am J Respir Cell Mol Biol. 2012 Jan;46(1):48-54. PMID: 22210825.

Mercado N, To Y, Kobayashi Y, et al. p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma. Mol Pharmacol. 2011 Dec;80(6):1128-35. PMID: 21917909.

Johnson M. Beta2-adrenoceptors: mechanisms of action of beta2-agonists. Paediatr Respir Rev. 2001 Mar;2(1):57-62. PMID: 16263481.

Custom Order

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