• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
AZD-3463

AZD-3463

Product ID A9600
Cas No. 1356962-20-3
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $85.90 In stock
5 mg $178.90 In stock
25 mg $422.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AZD-3463 is an inhibitor of anaplastic lymphoma kinase (ALK) and insulin-like growth factor 1 receptor (IGF-1R). This compound exhibits anticancer chemotherapeutic activity, inhibiting proliferation by altering downstream ERK/Akt/STAT3 signaling. AZD-3463 has induced regression or stasis in in vivo lung cancer tumor models and in several drug-resistant cell lines.

Product Info

Cas No.

1356962-20-3

Purity

≥99%

Formula

C24H25ClN6O

Formula Wt.

448.95

Chemical Name

N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl) pyrimidin-2-amine

IUPAC Name

N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl) pyrimidin-2-amine

Synonym

AZD3463

Solubility

In DMSO(24mg/ml), water with 1 eq. of acid, insoluble in ethanol

Appearance

Yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A9600 MSDS PDF

Info Sheet

A9600 Info Sheet PDF

References

Abstract: Yang B. Discovery of AZD3463 as a novel ALK/IGFR dual inhibitor and its ability in overcoming acquired resistance to crizotinib. Protein Kinases in Drug Discovery Conference. 2013.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B1640

    Benzydamine Hydrochloride

    NSAID; PG synthetase inhibitor.

    ≥98%
  • E7578

    Estramustine

    Nitrogen mustard and estradiol derivative; micr...

    ≥97%
  • G1652

    Genistein

    Phytoestrogen, isoflavone found in various plan...

    ≥98%
  • D3431

    3,4-Dihydroxyphenyl Ethanol

    Polyphenol found in olive oil, antioxidant.

    ≥95%
  • G0250

    cGAMP Disodium [STING Ligand]

    Cyclic dinucleotide that detects cytosolic DNA ...

    ≥98%
  • G5874

    Gossypol

    Polyphenol found in Gossypium; calcineurin and ...

    ≥98%
  • I7447

    1-Isothiocyanato-6-(methylsulfenyl)-hexane

    Synthetic ITC, erucin analog.

    ≥98%
  • T1024

    Baccatin VI

    Fermentation impurity

    ≥98%
  • Z7477

    ZSTK474

    PI3K inhibitor.

    ≥98%
  • L3374

    Lisinopril Dihydrate

    Enalapril analog; ACE inhibitor.

    ≥98%
  • T9969

    Tyrphostin AG490

    JAK2 inhibitor, potential EGFR inhibitor.

    ≥98%
  • T3305

    Tibolone

    Synthetic steroid hormone used in HRT; SERM, PR...

    ≥98%
  • M0803

    MC1568

    HDAC inhibitor. May reduce blood pressure in hy...

    ≥98%
  • N1978

    Neurokinin B

    Neuromodulator, biomarker

    ≥95%
  • E4416

    Eledoisin

    Peptide, substance P analog; NK agonist.

    ≥95%
  • O4531

    Oligomycin A

    Macrolide; F1F0 ATP synthase inhibitor.

    ≥97%, TLC, HPLC
  • L1044

    LCL-161

    SMAC mimetic; PXR agonist, IAP inhibitor.

    ≥99%, ≥99%ee, de
  • K0282

    Kavalactones Mixture

    Mixture of kavalactones found in Piper methysti...

    ≥98%
  • M5877

    Motesanib Diphosphate

    VEGFR, PDGFR, c-Kit, RET inhibitor.

    ≥98%
  • I5203

    Inauhzin

    p53 activator, IMPDH and SIRT1 inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only