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AZD-3463

AZD-3463

Product ID A9600
Cas No. 1356962-20-3
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $85.90 In stock
5 mg $178.90 In stock
25 mg $422.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AZD-3463 is an inhibitor of anaplastic lymphoma kinase (ALK) and insulin-like growth factor 1 receptor (IGF-1R). This compound exhibits anticancer chemotherapeutic activity, inhibiting proliferation by altering downstream ERK/Akt/STAT3 signaling. AZD-3463 has induced regression or stasis in in vivo lung cancer tumor models and in several drug-resistant cell lines.

Product Info

Cas No.

1356962-20-3

Purity

≥99%

Formula

C24H25ClN6O

Formula Wt.

448.95

Chemical Name

N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl) pyrimidin-2-amine

IUPAC Name

N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl) pyrimidin-2-amine

Synonym

AZD3463

Solubility

In DMSO(24mg/ml), water with 1 eq. of acid, insoluble in ethanol

Appearance

Yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A9600 MSDS PDF

Info Sheet

A9600 Info Sheet PDF

References

Abstract: Yang B. Discovery of AZD3463 as a novel ALK/IGFR dual inhibitor and its ability in overcoming acquired resistance to crizotinib. Protein Kinases in Drug Discovery Conference. 2013.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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