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AZD4320

AZD4320

Product ID A990144
Cas No. 1357576-48-7
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $110.30 In stock
5 mg $215.00 In stock
10 mg $325.30 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AZD4320 is an inhibitor that targets Bcl-2 and Bcl-xl. It has been found to kill tumor cells in vitro.

Product Info

Cas No.

1357576-48-7

Purity

≥99%

Formula

C45H48ClF3N4O7S3

Formula Wt.

945.53

Chemical Name

4-[4-[(R)-[2-(4-chlorophenyl)phenyl]-hydroxymethyl]piperidin-1-yl]-N-[4-[[(2R)-4-[2-hydroxyethyl(methyl)amino]-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide

IUPAC Name

4-[4-[(R)-[2-(4-chlorophenyl)phenyl]-hydroxymethyl]piperidin-1-yl]-N-[4-[[(2R)-4-[2-hydroxyethyl(methyl)amino]-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide

Synonym

AZD-4320; UNII-LH1ZTY91OR; LH1ZTY91OR; 4-(4-((R)-(4'-Chloro(1,1'-biphenyl)-2-yl)hydroxymethyl)-1-piperidinyl)-N-((4-(((1R)-3-((2-hydroxyethyl)methylamino)-1-((phenylthio)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

A990144 Info Sheet PDF

References

Arulananda S, O’Brien M, Evangelista M, et al. A novel BH3-mimeticm AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma. Cell Death Discov. 2021 May 28;7(1):122. PMID: 34050131

Patterson C, Balachander S, Grant I, et al. Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy. Commun Biol. 2021 Jan 25;4(1):112. PMID: 33495510

Balachander S, Criscione S, Byth K, et al. AZD4320, a dual inhibitor of Bcl-2 and Bcl-xL, induces tumor regression in hematologic cancer models without dose-limiting thrombocytopenia. Clin Cancer Res. 2020 Dec 15;26(24):6535-6549. PMID: 32988967

Custom Order

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