Description
AZD4320 is an inhibitor that targets Bcl-2 and Bcl-xl. It has been found to kill tumor cells in vitro.
AZD4320
Product ID A990144
Cas No. 1357576-48-7
Purity ≥99%
| Product Unit Size | Cost | Quantity | Stock |
|---|
Product Info
| Cas No. | 1357576-48-7 |
|---|---|
| Purity | ≥99% |
| Formula | C45H48ClF3N4O7S3 |
| Formula Wt. | 945.53 |
| Chemical Name | 4-[4-[(R)-[2-(4-chlorophenyl)phenyl]-hydroxymethyl]piperidin-1-yl]-N-[4-[[(2R)-4-[2-hydroxyethyl(methyl)amino]-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide |
| IUPAC Name | 4-[4-[(R)-[2-(4-chlorophenyl)phenyl]-hydroxymethyl]piperidin-1-yl]-N-[4-[[(2R)-4-[2-hydroxyethyl(methyl)amino]-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide |
| Synonym | AZD-4320; UNII-LH1ZTY91OR; LH1ZTY91OR; 4-(4-((R)-(4'-Chloro(1,1'-biphenyl)-2-yl)hydroxymethyl)-1-piperidinyl)-N-((4-(((1R)-3-((2-hydroxyethyl)methylamino)-1-((phenylthio)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| Info Sheet |
|---|
References
Arulananda S, O’Brien M, Evangelista M, et al. A novel BH3-mimeticm AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma. Cell Death Discov. 2021 May 28;7(1):122. PMID: 34050131
Patterson C, Balachander S, Grant I, et al. Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy. Commun Biol. 2021 Jan 25;4(1):112. PMID: 33495510
Balachander S, Criscione S, Byth K, et al. AZD4320, a dual inhibitor of Bcl-2 and Bcl-xL, induces tumor regression in hematologic cancer models without dose-limiting thrombocytopenia. Clin Cancer Res. 2020 Dec 15;26(24):6535-6549. PMID: 32988967