BAY 11-7082

Name: BAY 11-7082
SKU: B030966
Availability: InStock

Product ID B030966

Cas No. 19542-67-7

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

BAY 11-7082 is an inhibitor of IkappaBalpha phosphorylation and degradation. Treatment of multiple myeloma cells with BAY 11-7082 has been shown to induce rapid swelling followed by disintegration of the cell body. Studies have shown that BAY 11-7082 inhibits not only NF-kB, but in addition inhibits many components of inflammatory signaling pathways including PI3K/Akt/IKK/NFkB, ERK/JNK/AP-1, TBK1/IRF-3, and Jak-2/STAT-1. BAY 11-7082 has also been found to target the NLRP3 inflammasome pathway at many levels.

Product Info

Cas No.	19542-67-7
Purity	≥98%
Formula	C₁₀H₉NO₂S
Formula Wt.	207.25
Chemical Name	3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile
IUPAC Name	(2E)-3-[(4-Methylphenyl)sulfonyl]acrylonitrile
Synonym	(E)-3-(p-Toluenesulfonyl)acrylonitrile
Solubility	Soluble in DMSO (>25 mg/ml), ethanol (15 mg/ml), methanol, dichloromethane, DMF (~25 mg/ml), and 1:3 DMF:PBS (pH 7.2) (~0.25 mg/ml). Insoluble in water, and sparingly soluble in aqueous buffers.
Appearance	White poweder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	B030966 MSDS PDF
Info Sheet	B030966 Info Sheet PDF

References

Goffi F, Boroni F, Benarese M, et al. The inhibitor of I kappa B alpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices. Neurosci Lett. 2005 Apr 4;377(3):147-151. PMID: 15755516.

Rauert-Wunderlich H, Siegmund D, Maier E, et al. The IKK inhibitor BAY 11-7082 induces cell death independent from inhibition of activation of NFkB transcription factors. PLoS One. 2013;8(3):e59292. PMID: 23527154.

Strickson S, Campbell DG, Emmerich CH, et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signaling network by targeting the ubiquitin system. Biochem J. 2013 May 1;451(3):427-437. PMID: 23441730.

Lee J, Rhee MH, Kim E, et al. BAY 11-7082 is a broad-spectrum inhibitor with anti-inflammatory activity against multiple targets. Mediators Inflamm. 2012;2012:416036. PMID: 27745523.

Juliana C, Fernandes-Alnemri T, Wu J, et al. Anti-inflammatory compounds parthenolide and BAY 11-7082 are direct inhibitors of the inflammasome. J Biol Chem. 2010 Mar 26;285(13):9792-9802. PMID: 20093358.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Comments
This field is for validation purposes and should be left unchanged.

BAY 11-7082

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Eprosartan Mesylate

Hemorphin-7

α-Zearalanol

Bongkrekic Acid

Acepromazine Maleate

Sulfamethoxazole

Salmon Calcitonin Acetate

S-(N-3-Phenylpropylthiocarbamoyl)-L-cysteine

Hydrolyzed Fumonisin B1

Deoxyandrographolide

Bryostatin 1

(−)-Epicatechin Gallate

Tandutinib

Tanshinone I

LY-364947

Pirarubicin

SGX-523

Oleanolic Acid

Sitagliptin Phosphate Monohydrate

Penitrem A

Footer