LKT Labs

Biochemicals for Life Science Research

BAY 11-7082

BAY 11-7082

Product ID B030966
Cas No. 19542-67-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $60.10 In stock
10 mg $90.30 In stock
25 mg $165.40 In stock
100 mg $450.80 In stock
Bulk Quote

Quicklinks

Description

BAY 11-7082 is an inhibitor of IkappaBalpha phosphorylation and degradation. Treatment of multiple myeloma cells with BAY 11-7082 has been shown to induce rapid swelling followed by disintegration of the cell body. Studies have shown that BAY 11-7082 inhibits not only NF-kB, but in addition inhibits many components of inflammatory signaling pathways including PI3K/Akt/IKK/NFkB, ERK/JNK/AP-1, TBK1/IRF-3, and Jak-2/STAT-1. BAY 11-7082 has also been found to target the NLRP3 inflammasome pathway at many levels.

Product Info

Cas No.

19542-67-7
Purity

≥98%
Formula

C10H9NO2S
Formula Wt.

207.25
Chemical Name

3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile
IUPAC Name

(2E)-3-[(4-Methylphenyl)sulfonyl]acrylonitrile
Synonym

(E)-3-(p-Toluenesulfonyl)acrylonitrile
Solubility

Soluble in DMSO (>25 mg/ml), ethanol (15 mg/ml), methanol, dichloromethane, DMF (~25 mg/ml), and 1:3 DMF:PBS (pH 7.2) (~0.25 mg/ml). Insoluble in water, and sparingly soluble in aqueous buffers.
Appearance

White poweder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

B030966 MSDS PDF
Info Sheet

B030966 Info Sheet PDF

References

Goffi F, Boroni F, Benarese M, et al. The inhibitor of I kappa B alpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices. Neurosci Lett. 2005 Apr 4;377(3):147-151. PMID: 15755516.

Rauert-Wunderlich H, Siegmund D, Maier E, et al. The IKK inhibitor BAY 11-7082 induces cell death independent from inhibition of activation of NFkB transcription factors. PLoS One. 2013;8(3):e59292. PMID: 23527154.

Strickson S, Campbell DG, Emmerich CH, et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signaling network by targeting the ubiquitin system. Biochem J. 2013 May 1;451(3):427-437. PMID: 23441730.

Lee J, Rhee MH, Kim E, et al. BAY 11-7082 is a broad-spectrum inhibitor with anti-inflammatory activity against multiple targets. Mediators Inflamm. 2012;2012:416036. PMID: 27745523.

Juliana C, Fernandes-Alnemri T, Wu J, et al. Anti-inflammatory compounds parthenolide and BAY 11-7082 are direct inhibitors of the inflammasome. J Biol Chem. 2010 Mar 26;285(13):9792-9802. PMID: 20093358.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M9643

    Myelin Basic Protein (1-11), human

    Peptide antigen fragment

    ≥95%
  • Z161025

    β-Zearalenol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • C9612

    Cyclosporin C

    Cyclosporin metabolite; weak calmodulin inhibitor....
    ≥98%
  • F334453

    Filipin III

    Antifungal antibiotic

    ≥95%
  • A7210

    L-(+)-Ascorbic Acid

    Form of vitamin C found in various plant and fo...

    ≥98%
  • O486180

    Omeprazole Related Compound A

    Impurity of omeprazole

    ≥99%
  • C1600

    Carcinoembryonic Antigen (605-613)

    Carcinoembryonic antigen epitope.

    ≥95%
  • P1760

    Peptide T

    Peptide fragment of HIV-1 gp120.

    ≥98%
  • T3034

    Thienylethyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • D9752

    Dynasore

    Dynamin inhibitor.

    ≥98%
  • K0031

    Kahweol Acetate

    Diterpene found in coffee beans.

    ≥98%
  • D0004

    Dabrafenib

    B-Raf and c-Raf inhibitor.

    ≥98%
  • Z324098

    Ziconotide

    Non-opioid analgesic.

    ≥95%
  • S9775

    Systemin

    Peptide hormone found in Solanaceae family plan...

    ≥95%
  • S0501

    SB-939

    HDAC inhibitor.

    ≥98%
  • R3197

    Rhynchophylline

    Oxyindole alkaloid found in Uncaria sinensis; h...

    ≥98%
  • B6935

    Brivudine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥98%
  • L960002

    LY-294002 Hydrochloride

    Inhibitor of PI3K.

    ≥98%
  • N1976

    Netilmicin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • B1878

    Betamethasone 21-Phosphate Sodium

    Steroid; glucocorticoid agonist.

    ≥98%