• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Bisdemethoxycurcumin

Bisdemethoxycurcumin

Product ID B3573
Cas No. 24939-16-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $145.80 In stock
10 mg $194.70 In stock
25 mg $292.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Bisdemethoxycurcumin, like its parent compound curcumin, exhibits anticancer, antioxidative, anti-diabetic, anti-inflammatory, and antibacterial activities. Bisdemethoxycurcumin inhibits Wnt signaling by inhibiting WIF-1 promoter demethylation and inhibits DNA methyltransferase 1 (DNMT1), inducing apoptosis in non-small cell lung cancer (NSCLC) cells. Bisdemethoxycurcumin also induces apoptosis in other in vitro cancer models through increases in reactive oxygen species (ROS) and increases in the expression of p53, p21, p16, and retinoblastoma (Rb) protein. This compound activates SIRT1 and AMPK signaling. Bisdemethoxycurcumin inhibits PDGF signaling in smooth muscle cells, preventing cell migration and proliferation. Bisdemethoxycurcumin may also display potential benefit in the treatment of type 2 diabetes, as it acts as a noncompetitive inhibitor of pancreatic α-amylase. Like other curcuminoids, this compound also displays phototoxic antibacterial activity, although it is active primarily against gram-positive bacteria only.

Product Info

Cas No.

24939-16-0

Purity

≥98%

Formula

C19H16O4

Formula Wt.

308.33

Chemical Name

1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-

IUPAC Name

(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

Solubility

DMSO

Appearance

orange powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B3573 MSDS PDF

Info Sheet

B3573 Info Sheet PDF

Brochures

Curcumin Flyer

Natural Products Booklet

WNT Booklet

Epigenetic Modifiers Booklet

References

Li YB, Zhong ZF, Chen MW, et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med. 2013;2013:851714. Epub 2013 Sep 2. PMID: 24078830.

Li YB, Gao JL, Zhong ZF, et al. Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 2013;65(3):700-9. PMID: 23950593.

Hua Y, Dolence J, Ramanan S, et al. Bisdemethoxycurcumin inhibits PDGF-induced vascular smooth muscle cell motility and proliferation. Mol Nutr Food Res. 2013 Sep;57(9):1611-8. PMID: 23554078.

Ponnusamy S, Zinjarde S, Bhargava S, et al. Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes. Food Chem. 2012 Dec 15;135(4):2638-42. PMID: 22980852.

Liu YL, Yang HP, Zhou XD, et al. The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancer. Curr Cancer Drug Targets. 2011 Nov;11(9):1098-110. PMID: 21933103.

Haukvik T, Bruzell E, Kristensen S, et al. A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. Pharmazie. 2011 Jan;66(1):69-74. PMID: 21391438.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • K0088

    Kawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • C8501

    CV-66

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥60%
  • A5373

    Anisomycin

    Peptidyl transferase inhibitor, protein transla...

    ≥98%
  • D4873

    Meso-2,3-dimercaptosuccinic Acid

    Organosulfur, chelating agent.

    ≥98%
  • D0808

    DCC-2036

    Abl inhibitor.

    ≥98%
  • F1652

    Fenbufen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • S1060

    Small Cardioactive Peptide A

    Peptide found in molluscs, cardiomodulator.

    ≥95%
  • C4759

    Clozapine N-oxide

    Inert clozapine analog, activates specialized GPCR...
    ≥98%
  • D5611

    Docosahexaenoic Acid (all cis-4,7,10,13,16,19) Methyl Ester

    Essential fatty acid found in fish oil, involve...

    ≥99%
  • C9200

    CX-6258

    Pim kinase inhibitor.

    ≥98%
  • H3272

    His Tag

    Six-histidine peptide used for affinity column ...

    ≥98%
  • K0282

    Kavalactones Mixture

    Mixture of kavalactones found in Piper methysti...

    ≥98%
  • A0401

    Abacavir

    Nucleoside (guanosine) analog; RT, guanylyl cyc...

    ≥98%
  • S3346

    Silodosin

    α1A-adrenergic antagonist.

    ≥98%
  • S164098

    Seco-rapamycin

    Rapamycin analog

    ≥73%
  • C0170

    N-(4-Carbethoxyphenyl)retinamide

    Retinoid, differentiation inducer.

    ≥98%
  • G4532

    Gliclazide

    Sulfonylurea; SUR1 antagonist.

    ≥98%
  • T6933

    Trichostatin A

    HDAC inhibitor, mammalian RNA splicing modulato...

    ≥98%
  • G3554

    Ginsenoside Rb3

    Triterpene saponin found in species of Panax.

    ≥98%
  • H5654

    Honokiol

    Lignan found in species of Magnolia; GABA-A pot...

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only