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Bongkrekic acid is an antioxidative compound that inhibits mitochondrial respiration by preventing the mitochondrial permeability transition (MPT); it suppresses transport of ADP/ATP across the mitochondrial inner membrane, decreasing oxidative stress.
| Cas No. | 11076-19-0 |
|---|---|
| Purity | ≥95% |
| Formula | C28H38O7 |
| Formula Wt. | 486.60 |
| Chemical Name | 3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,14,18,20-heptaenedioic acid |
| IUPAC Name | (2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)-20-(carboxymethyl)-6-methoxy-2,5, 17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid |
| Synonym | Bongkrek acid; Flavotoxin A; L7V4I673D2; C28H38O7 |
| Melting Point | 50-60°C |
| Solubility | Soluble as 2N in NH4OH. |
| Appearance | White solid |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Nolly MB, Caldiz CI, Yeves AM, et al. The signaling pathway for aldosterone-induced mitochondrial production of superoxide anion in the myocardium. J Mol Cell Cardiol. 2014 Feb;67:60-8. PMID: 24355174.
Rey M, Forest E, Pelosi L. Exploring the conformational dynamics of the bovine ADP/ATP carrier in mitochondria. Biochemistry. 2012 Dec 4;51(48):9727-35. PMID: 23136955.