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Busulfan

Busulfan

Product ID B7973
Cas No. 55-98-1
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $45.50 In stock
25 g $90.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Busulfan is an alkyl sulfonate that exhibits anticancer chemotherapeutic activity. Busulfan is an alkylating agent that attaches an alkyl group to the N7 position of guanine bases, inhibiting DNA replication; it is clinically used to treat chronic myelogenous leukemia (CML). In vitro, busulfan inhibits growth of promyelocytic leukemia cells. This compound may also induce senescence in normal cells through activation of ERK and p38 MAPK signaling.

Product Info

Cas No.

55-98-1

Purity

≥98%

Formula

C6H14O6S2

Formula Wt.

246.30

Chemical Name

1,4-Butanediol dimethanesulfonate esters

IUPAC Name

4-methylsulfonyloxybutyl methanesulfonate

Synonym

Busulphan

Melting Point

287°C

Solubility

Soluble in acetone (22 mg/mL), ethanol, or DMSO. Insoluble in water.

Appearance

White crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B7973 MSDS PDF

Info Sheet

B7973 Info Sheet PDF

References

Galaup A, Paci A. Pharmacology of dimethanesulfonate alkylating agents: busulfan and treosulfan. Expert Opin Drug Metab Toxicol. 2013 Mar;9(3):333-47. PMID: 23157726.

Probin V, Wang Y, Zhou D. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med. 2007 Jun 15;42(12):1858-65. PMID: 17512465.

Frame D. Chronic myeloid leukemia: standard treatment options. Am J Health Syst Pharm. 2006 Dec 1;63(23 Suppl 8):S10-4; quiz S21-2. PMID: 17106015.

Iwamoto T, Hiraku Y, Oikawa S, et al. DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect. Cancer Sci. 2004 May;95(5):454-8. PMID: 15132775.

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