Description
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
| Cas No. | 1243243-89-1 |
|---|---|
| Purity | ≥98% |
| Formula | C25H21N3O |
| Formula Wt. | 379.45 |
| Chemical Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
| IUPAC Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
| Synonym | Wnt-C59 |
| Solubility | DMSO 76 mg/mL (200.28 mM) Water Insoluble Ethanol Insoluble |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Proffitt KD, Madan B, Ke Z, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73(2):502-7. PMID: 23188502.
NS3/4A serine protease inhibitor.
NSAID; COX-2 inhibitor.
Aldosterone antagonist.
Isoquinoline alkaloid found in Corydalis, Phell...
PP2A inhibitor.
Neuroactive mycotoxin produced by Penicillum an...
c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5...
Diaminoquinazoline derivative.
Polyphenol derivative of caffeic acid found in ...
Cysteine-ITC conjugate, BITC derivative, antiox...
Alpha blocker and vasoactive agent.
Mineralocorticoid antagonist.
Geldanamycin derivative; HSP90 inhibitor.
Potential p53 activator or SIRT2 inhibitor.
Akt inhibitor.
Taxoid that disrupts the microtubular network i...
NMDA partial agonist, D-Ala-D-Ala ligase inhibi...
FIASMA, mAChR, 5-HT2/3/6/7, α1/2-adrenergic an...
Phenol found in various plant sources, used to ...
PKA and PDK1 inhibitor, HCN channel blocker, po...