| Product Unit Size | Cost | Quantity | Stock |
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This peptide inhibits calcineurin phosphatase activity and is used to examine the effects of calcineurin in research studies. In cellular models, this peptide inhibits calcineurin-induced glutamate-mediated neuronal cell death and decreases L-type Ca2+ channel currents.
| Cas No. | 148067-21-4 |
|---|---|
| Purity | ≥95% |
| Formula | C124H205N39O39S2 |
| Formula Wt. | 2930.38 |
| Solubility | Soluble in water, acid. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Terada H, Matsushita M, Lu YF, et al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec;87(5):1145-51. PMID: 14622094.
Norris CM, Blalock EM, Chen KC, et al. Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture. Neuroscience. 2002;110(2):213-25. PMID: 11958864.
Perrino BA. Regulation of calcineurin phosphatase activity by its autoinhibitory domain. Arch Biochem Biophys. 1999 Dec 1;372(1):159-65. PMID: 10562429.