Description
Calphostin C is an inhibitor of PKC found in Cladosporium. Calphostin C exhibits anticancer activity, inducing apoptosis, increasing JNK and caspase activation, and stimulating PARP cleavage in breast cancer cells.
Calphostin C
Product ID C0344
Cas No. 121263-19-2
Purity ≥95%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 121263-19-2 |
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| Purity | ≥95% |
| Formula | C44H38O14 |
| Formula Wt. | 790.76 |
| IUPAC Name | 1-[3,10-dihydroxy-12-[2-(4-hydroxyphenoxy)carbonyloxypropyl]-2,6,7, 11-tetramethoxy-4,9-dioxoperylen-1-yl]propan-2-yl benzoate |
| Synonym | UCN-1028c |
| Solubility | Soluble in DMSO, ethanol, or DMF. |
| Appearance | Dark Red Solid |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
De Vita F, Riccardi M, Malanga D, et al. PKC-dependent phosphorylation of p27 at T198 contributes to p27 stabilization and cell cycle arrest. Cell Cycle. 2012 Apr 15;11(8):1583-92. PMID: 22441823.
Robitaille K, Daviau A, Lachance G, et al. Calphostin C-induced apoptosis is mediated by a tissue transglutaminase-dependent mechanism involving the DLK/JNK signaling pathway. Cell Death Differ. 2008 Sep;15(9):1522-31. PMID: 18497756.
Kobayashi E, Ando K, Nakano H, et al. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1989 Oct;42(10):1470-4. PMID: 2478514.