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CGK733 is an inhibitor of ATM and ATR kinases that prevents double-stranded DNA strand break repair. CGK733 displays anticancer activity, decreases expression of p21 in senescent cells and induces cell death in cancer cells and fibroblasts.
| Cas No. | 905973-89-9 |
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| Purity | ≥98% |
| Formula | C23H18Cl3FN4O3S |
| Formula Wt. | 555.83 |
| IUPAC Name | 2,2-Diphenyl-N-(2,2,2-trichloro-1-{[(4-fluoro-3-nitrophenyl)carbamothioyl]amino}ethyl)acetamide |
| Synonym | CGK733, CGK 733, ATM/ATR Kinase Inhibitor |
| Solubility | DMSO Solubility: 100 mg/mL (179.9 mM) |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Jekimovs C, Bolderson E, Suraweera A, et al. Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising. Front Oncol. 2014 Apr 22;4:86. PMID: 24795863.
Alao JP, Sunnerhagen P. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat Oncol. 2009 Nov 10;4:51. PMID: 19903334.