Chlorpromazine Hydrochloride

Name: Chlorpromazine Hydrochloride
SKU: C2947
Availability: InStock

Product ID C2947

Cas No. 69-09-0

Purity ≥98%

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Description

Chlorpromazine is a phenothiazine that exhibits antipsychotic, antidepressant, anxiolytic, neuroprotective, and anticancer chemotherapeutic activities. Chlorpromazine inhibits D1/2/3/4 receptors, 5-HT1/2 receptors, α1/2-adrenergic receptors, and M1/2 muscarinic acetylcholine receptors (mAChRs). Chlorpromazine stabilizes misfolding motifs of prions, preventing oligomerization. Additionally, this compound acts as a functional inhibitor of acid sphingomyelinase (FIASMA). In vivo, chlorpromazine induces autophagy and apoptosis, inhibiting growth of glioma tumors.

Product Info

Cas No.	69-09-0
Purity	≥98%
Formula	C₁₇H₁₉ClN₂S • HCl
Formula Wt.	355.33
Chemical Name	2-Chloro-N,N-dimethyl-10H-phenothiazine-10- propanamine hydrochloride
IUPAC Name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
Synonym	Hebanil, Klorpromex, Largactil, Megaphen, Promacid, Chloractil, Sonazine, Marazine, Taroctyl, Torazina
Melting Point	179-180°C(dec.)
Solubility	Soluble in methanol, ethanol (660 mg/mL), chloroform or water (1 g/mL). Insoluble in ether, or benzene.
Appearance	White Crystal Powder

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Store Temp	Ambient
Ship Temp	Ambient

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MSDS	C2947 MSDS PDF
Info Sheet	C2947 Info Sheet PDF

References

Baral PK, Swayampakula M, Rout MK, et al. Structural basis of prion inhibition by phenothiazine compounds. Structure. 2014 Feb 4;22(2):291-303. PMID: 24373770.

Ramos MA. Drugs in context: a historical perspective on theories of psychopharmaceutical efficacy. J Nerv Ment Dis. 2013 Nov;201(11):926-33. PMID: 24177478.

Shin SY, Lee KS, Choi YK, et al. The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis. 2013 Sep;34(9):2080-9. PMID: 23689352.

Baumeister AA. The chlorpromazine enigma. J Hist Neurosci. 2013;22(1):14-29. PMID: 23323529.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

Peroutka SJ, Synder SH. Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency. Am J Psychiatry. 1980 Dec;137(12):1518-22. PMID: 6108081.

Masuda K, Kimura A, Hanieh H, et al. Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages. Int Immunol. 2011 Oct;23(10):637-645. PMID: 21930594.

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Chlorpromazine Hydrochloride

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