LKT Labs

Biochemicals for Life Science Research

Chlorpromazine Hydrochloride

Chlorpromazine Hydrochloride

Product ID C2947
Cas No. 69-09-0
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $78.00 In stock
25 g $109.00 In stock
100 g $325.00 In stock
Bulk Quote

Quicklinks

Description

Chlorpromazine is a phenothiazine that exhibits antipsychotic, antidepressant, anxiolytic, neuroprotective, and anticancer chemotherapeutic activities. Chlorpromazine inhibits D1/2/3/4 receptors, 5-HT1/2 receptors, α1/2-adrenergic receptors, and M1/2 muscarinic acetylcholine receptors (mAChRs). Chlorpromazine stabilizes misfolding motifs of prions, preventing oligomerization. Additionally, this compound acts as a functional inhibitor of acid sphingomyelinase (FIASMA). In vivo, chlorpromazine induces autophagy and apoptosis, inhibiting growth of glioma tumors.

Product Info

Cas No.

69-09-0
Purity

≥98%
Formula

C17H19ClN2S • HCl
Formula Wt.

355.33
Chemical Name

2-Chloro-N,N-dimethyl-10H-phenothiazine-10- propanamine hydrochloride
IUPAC Name

3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
Synonym

Hebanil, Klorpromex, Largactil, Megaphen, Promacid, Chloractil, Sonazine, Marazine, Taroctyl, Torazina
Melting Point

179-180°C(dec.)
Solubility

Soluble in methanol, ethanol (660 mg/mL), chloroform or water (1 g/mL). Insoluble in ether, or benzene.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C2947 MSDS PDF
Info Sheet

C2947 Info Sheet PDF

References

Baral PK, Swayampakula M, Rout MK, et al. Structural basis of prion inhibition by phenothiazine compounds. Structure. 2014 Feb 4;22(2):291-303. PMID: 24373770.

Ramos MA. Drugs in context: a historical perspective on theories of psychopharmaceutical efficacy. J Nerv Ment Dis. 2013 Nov;201(11):926-33. PMID: 24177478.

Shin SY, Lee KS, Choi YK, et al. The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis. 2013 Sep;34(9):2080-9. PMID: 23689352.

Baumeister AA. The chlorpromazine enigma. J Hist Neurosci. 2013;22(1):14-29. PMID: 23323529.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

Peroutka SJ, Synder SH. Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency. Am J Psychiatry. 1980 Dec;137(12):1518-22. PMID: 6108081.

Masuda K, Kimura A, Hanieh H, et al. Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages. Int Immunol. 2011 Oct;23(10):637-645. PMID: 21930594.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V3277

    Vitamin E

    Synthetic vitamin E, antioxidant.

    ≥98%
  • M1605

    Mebendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • B8274

    Buspirone Hydrochloride

    Azapirone; α1-adrenergic and 5-HT1A partial ag...

    ≥98%
  • A4845

    Amylin (8-37), rat

    Endogenous peptide hormone inolved in gastric e...

    ≥95%
  • W317520

    WIN 55,212-2 Mesylate

    Non-selective cannabinoid receptor agonist.

    ≥98%
  • C446176

    Clemastine Fumarate

    Antihistamine with potential neuroprotective ac...

    ≥99%
  • B5728

    Bohemine

    Purine derivative; CDK inhibitor.

    ≥98%
  • F5766

    Forchlorfenuron

    Synthetic cytokinin, plant growth regulator; fi...

    ≥98%
  • K1679

    (+)-Ketanserin Tartrate

    5-HT2A and TRPV1 antagonist, potential α1-adre...

    ≥98%
  • I0010

    5-(9-Isopropyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine

    Intermediate in the synthesis of purine analogs...

    ≥98%
  • P3441

    PIK-294

    p110δ PI3K inhibitor.

    ≥98%
  • P0244

    Palbociclib Hydrochloride

    CDK4/6 inhibitor.

    ≥99%
  • A1370

    Adrenomedullin (22-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%
  • P9869

    Pyridoxine Hydrochloride

    Vitamin B6 derivative, antioxidant.

    ≥98%
  • I544766

    Intepirdine

    Selective 5-HT6 receptor antagonist

    ≥98%
  • A5130

    Amphotericin B

    Polyene, binds ergosterol and induces membrane ...

    ≥90%
  • G0044

    Galantide

    Peptide; galanin antagonist.

    ≥95%
  • W0272

    S-(−)-Warfarin >99%ee

    Coumarin, more potent isomer; VKORC1 inhibitor....

    ≥99%
  • H3273

    Histatin 5

    Endogenous antimicrobial peptide, binds bacteri...

    ≥95%
  • G4479

    Glucagon (19-29), human

    Endogenous peptide hormone, glugagon fragment; ...

    ≥95%