Chlorpromazine Hydrochloride

Name: Chlorpromazine Hydrochloride
SKU: C2947
Availability: InStock

Product ID C2947

Cas No. 69-09-0

Purity ≥98%

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Description

Chlorpromazine is a phenothiazine that exhibits antipsychotic, antidepressant, anxiolytic, neuroprotective, and anticancer chemotherapeutic activities. Chlorpromazine inhibits D1/2/3/4 receptors, 5-HT1/2 receptors, α1/2-adrenergic receptors, and M1/2 muscarinic acetylcholine receptors (mAChRs). Chlorpromazine stabilizes misfolding motifs of prions, preventing oligomerization. Additionally, this compound acts as a functional inhibitor of acid sphingomyelinase (FIASMA). In vivo, chlorpromazine induces autophagy and apoptosis, inhibiting growth of glioma tumors.

Product Info

Cas No.	69-09-0
Purity	≥98%
Formula	C₁₇H₁₉ClN₂S • HCl
Formula Wt.	355.33
Chemical Name	2-Chloro-N,N-dimethyl-10H-phenothiazine-10- propanamine hydrochloride
IUPAC Name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
Synonym	Hebanil, Klorpromex, Largactil, Megaphen, Promacid, Chloractil, Sonazine, Marazine, Taroctyl, Torazina
Melting Point	179-180°C(dec.)
Solubility	Soluble in methanol, ethanol (660 mg/mL), chloroform or water (1 g/mL). Insoluble in ether, or benzene.
Appearance	White Crystal Powder

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Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	C2947 MSDS PDF
Info Sheet	C2947 Info Sheet PDF

References

Baral PK, Swayampakula M, Rout MK, et al. Structural basis of prion inhibition by phenothiazine compounds. Structure. 2014 Feb 4;22(2):291-303. PMID: 24373770.

Ramos MA. Drugs in context: a historical perspective on theories of psychopharmaceutical efficacy. J Nerv Ment Dis. 2013 Nov;201(11):926-33. PMID: 24177478.

Shin SY, Lee KS, Choi YK, et al. The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis. 2013 Sep;34(9):2080-9. PMID: 23689352.

Baumeister AA. The chlorpromazine enigma. J Hist Neurosci. 2013;22(1):14-29. PMID: 23323529.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

Peroutka SJ, Synder SH. Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency. Am J Psychiatry. 1980 Dec;137(12):1518-22. PMID: 6108081.

Masuda K, Kimura A, Hanieh H, et al. Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages. Int Immunol. 2011 Oct;23(10):637-645. PMID: 21930594.

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Chlorpromazine Hydrochloride

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