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Chrysophanol

Chrysophanol

Product ID C2970
Cas No. 481-74-3
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $71.50 In stock
25 mg $102.00 In stock
100 mg $408.30 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Chrysophanol is an anthraquinone originally found in species of Rheum. Chrysophanol exhibits anti-inflammatory, antiviral, antibiotic, and anticancer activities. In animal models of cerebral ischemia/reperfusion, chrysophanol inhibits activation of the NALP3 inflammasome, ameliorating stroke-related pathology. Chrysophanol also decreases proliferation of Japanese encephalitis virus in vitro and displays antibacterial activity against Mycobacterium tuberculosis. In lung cancer cells, this compound increases levels of ROS and decreases the mitochondrial membrane potential, inducing necrotic cell death.

Product Info

Cas No.

481-74-3

Purity

≥98%

Formula

C15H10O4

Formula Wt.

254.24

Chemical Name

1,8-Dihydroxy-3-methyl-9,10-anthracenedione, Chrysophanic acid

IUPAC Name

1,8-dihydroxy-3-methylanthracene-9,10-dione

Synonym

Chrysophanic acid, Turkey rhubarb.

Melting Point

196°C

Solubility

Practically insoluble in water, freely. Soluble in boiling alcohol, benzene or acetone.

Appearance

Gold yellow crystallized powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C2970 MSDS PDF

Info Sheet

C2970 Info Sheet PDF

References

Zhang N, Zhang X, Liu X, et al. Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice. Mediators Inflamm. 2014;2014:370530. PMID: 24876671.

Ni CH, Yu CS, Lu HF, et al. Chrysophanol-induced cell death (necrosis) in human lung cancer A549 cells is mediated through increasing reactive oxygen species and decreasing the level of mitochondrial membrane potential. Environ Toxicol. 2014 May;29(7):740-9. PMID: 22848001.

Chang SJ, Huang SH, Lin YJ, et al. Antiviral activity of Rheum palmatum methanol extract and chrysophanol against Japanese encephalitis virus. Arch Pharm Res. 2014 Jan 7. [Epub ahead of print]. PMID: 24395532.

Smolarz HD, Swatko-Ossor M, Ginalska G, et al. Antimycobacterial effect of extract and its components from Rheum rhaponticum. J AOAC Int. 2013 Jan-Feb;96(1):155-60. PMID: 23513971.

Custom Order

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