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Ciclesonide is an anti-inflammatory corticosteroid. Its active metabolite and several ciclesonide-acetal derivatives have been found to block RNA replication of the SARS-Cov-2 virus. Ciclesonide also inhibits lung cancer stem cells through Hedgehog signaling-mediated SOX2 regulation.
| Cas No. | 126544-47-6 |
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| Purity | ≥98% |
| Formula | C32H44O7 |
| Formula Wt. | 540.7 |
| Chemical Name | (R)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde, 21-isobutyrate |
| IUPAC Name | [2-[(1S,2S,4R,6R,8S,9S,11S,12S,13R)-6-cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 2-methylpropanoate |
| Synonym | Alvesco; Omnaris; Zetonna; RPR251526 |
| Solubility | Insoluble in water. Soluble in EtOH and DMSO. |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| Info Sheet |
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H. Kimura, H. Kurusu, M. Sada, et al. Molecular pharmacology of ciclesonide against SARS-CoV-2. J Allergy Clin Immunol. (2020) 146:330-331.
G. Tsuji, S. Nakajima, K. Watashi, et al. Antiviral activity of ciclesonide acetal derivatives blocking SARS-CoV-2 RNA replication. J Pharmacol Sci. (2022) 149:81-84.
S. Matsuyama, M. Kawase, N. Nao, The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells. J Virol. (2020) (95)1648-20.
H. S. Choi, S-L Kim, J-H Kim and D-S Lee. The FDA-Approved Anti-Asthma Medicine Ciclesonide Inhibits Lung Cancer Stem Cells through Hedgehog Signaling-Mediated SOX2 Regulation. Int J Mol Sci. (2020) 21:1014.