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Cinacalcet Hydrochloride

Cinacalcet Hydrochloride

Product ID C3352
Cas No. 364782-34-3
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $60.90 In stock
25 mg $194.30 In stock
100 mg $446.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cinacalcet is an agonist at Ca2+-sensing receptors that is clinically used to treat secondary hyperparathyroidism with chronic kidney disease. Cinacalcet also displays anti-fibrotic activity. This compound decreases levels of parathyroid hormone (PTH), increases adiponectin secretion, and lowers oxidative stress. This compound increases sensitivity of Ca2+-sensing receptors to serum Ca2+ levels. In vivo, cinacalcet decreases renal epithelial-to-mesenchymal transition (EMT) and prevents the development of renal fibrosis.

Product Info

Cas No.

364782-34-3

Purity

≥99%

Formula

C22H22F3N • HCl

Formula Wt.

393.87

IUPAC Name

N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine hydrochloride (1:1)

Solubility

100mM in DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C3352 MSDS PDF

Info Sheet

C3352 Info Sheet PDF

References

Kuczera P, Adamczak M, Machnik G, et al. Treatment with Cinacalcet Increases Plasma Adiponectin Concentration in Hemodialysed Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism. Endocr Pract. 2015 Mar 18:1-22. [Epub ahead of print]. PMID: 25786554.

Wu M, Tang RN, Liu H, et al. Cinacalcet attenuates the renal endothelial-to-mesenchymal transition in rats with adenine-induced renal failure. Am J Physiol Renal Physiol. 2014 Jan 1;306(1):F138-46. PMID: 24154694.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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