Description
Citalopram is a selective serotonin reuptake inhibitor (SSRI) that inhibits the serotonin transporter (SERT); citalopram is clinically used for its antidepressant and anxiolytic activities, although it may prolong the QT interval. The S-isomer of citalopram is active and is sold on its own as escitalopram. Citalopram also exhibits neuroprotective activity, increasing expression of BDNF and inhibiting neuronal apoptosis. Additionally, this compound displays anti-inflammatory benefit, inhibiting arthritis progression in vivo by suppressing TLR signaling and decreasing production of TNF, IL-6, and IFN-γ.