• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Clofarabine

Clofarabine

Product ID C4646
Cas No. 123318-82-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $97.70 In stock
10 mg $180.30 In stock
25 mg $338.00 In stock
100 mg $976.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Clofarabine is a second-generation nucleoside analog of adenosine. Clofarabine inhibits DNA polymerase and ribonucleotide reductase through binding in the A-site, preventing DNA synthesis. Clofarabine is clinically used to treat acute lymphoblastic leukemia (ALL) and is in clinical trials as a potential treatment for other leukemias. Clofarabine exhibits anticancer chemotherapeutic activity, acting as a cytotoxic agent. Clofarabine also binds A1, A2, and A3 adenosine receptors.

Product Info

Cas No.

123318-82-1

Purity

≥98%

Formula

C10H11ClFN5O3

Formula Wt.

303.68

Chemical Name

(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

IUPAC Name

(2R,3R,4S, 5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

Melting Point

228-231°C

Solubility

10mM H2O,100mM DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C4646 MSDS PDF

Info Sheet

C4646 Info Sheet PDF

References

Robak P, Robak T. Older and new purine nucleoside analogs for patients with acute leukemias. Cancer Treat Rev. 2013 Dec;39(8):851-61. PMID: 23566572.

Jensen K, Johnson LA, Jacobson PA, et al. Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):519-25. PMID: 22249336.

Majda K, Lubecka K, Kaufman-Szymczyk A, et al. Clofarabine (2-chloro-2'-fluoro-2'-deoxyarabinosyladenine)--biochemical aspects of anticancer activity. Acta Pol Pharm. 2011 Jul-Aug;68(4):459-66. PMID: 21796927.

Aye Y, Stubbe J. Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9815-20. PMID: 21628579.

Parker WB, Shaddix SC, Chang CH, et al. Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Res. 1991 May 1;51(9):2386-94. PMID: 1707752.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B1878

    Betamethasone 21-Phosphate Sodium

    Steroid; glucocorticoid agonist.

    ≥98%
  • E4902

    Emamectin B1 Benzoate

    Semi-synthetic avermectin; GABA potentiator.

    ≥80%
  • T3197

    L-Thyroxine Sodium Pentahydrate

    Endogenous thyroid hormone T4.

    ≥97%
  • R2712

    Recombinant HCV-NS3 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • G3455

    Ginsenoside Rc

    Triterpene saponin found in species of Panax; A...

    ≥98%
  • M5610

    Moclobemide

    MAO-A inhibitor.

    ≥98%
  • C086007

    CC-671

    TTK/CLK2 inhibitor.

    ≥98%
  • M1644

    Meloxicam

    NSAID; COX-2 inhibitor.

    ≥98%
  • X4402

    XL-147

    Dual inhibitor of PI3K and mTOR.

    ≥98%
  • M0248

    Manidipine Dihydrochloride

    Dihydropyridine; L-type and T-type Ca2+ channel...

    ≥99%
  • F4682

    Fluconazole

    Triazole; 14-α demethylase inhibitor.

    ≥98%
  • G7344

    GSK-2334470

    PI3K and PDK1 inhibitor.

    ≥99%, ≥99%ee
  • R3011

    Recombinant TpN 15 protein

    Recombinant protein containing Treponema pallid...

    ≥95%
  • I5414

    Indapamide

    Thiazide-like diuretic; Kv7.1 and minK K+ chann...

    ≥98%
  • C0175

    Carbetocin Acetate

    Peptide, oxytocin analog; potential OXTR agonis...

    ≥95%
  • A4853

    β-Amyloid Peptide (1-42), human

    Endogenous APP peptide cleavage product, primar...

    ≥95%
  • P6002

    PP-121

    p110α PI3K, DNA-PK, mTOR, Abl, Hck, Src, VEGFR...

    ≥98%
  • C1867

    Ceramide

    Endogenous sphingosine-based lipid, component of s...
    ≥98%
  • F4557

    Floxuridine

    5-Fluorouracil derivative, fluorinated pyrimidi...

    ≥98%
  • E6880

    Erucin

    Isothiocyanate found in cruciferous vegetables,...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only