• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Clofarabine

Clofarabine

Product ID C4646
Cas No. 123318-82-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $97.70 In stock
10 mg $180.30 In stock
25 mg $338.00 In stock
100 mg $976.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Clofarabine is a second-generation nucleoside analog of adenosine. Clofarabine inhibits DNA polymerase and ribonucleotide reductase through binding in the A-site, preventing DNA synthesis. Clofarabine is clinically used to treat acute lymphoblastic leukemia (ALL) and is in clinical trials as a potential treatment for other leukemias. Clofarabine exhibits anticancer chemotherapeutic activity, acting as a cytotoxic agent. Clofarabine also binds A1, A2, and A3 adenosine receptors.

Product Info

Cas No.

123318-82-1

Purity

≥98%

Formula

C10H11ClFN5O3

Formula Wt.

303.68

Chemical Name

(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

IUPAC Name

(2R,3R,4S, 5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

Melting Point

228-231°C

Solubility

10mM H2O,100mM DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C4646 MSDS PDF

Info Sheet

C4646 Info Sheet PDF

References

Robak P, Robak T. Older and new purine nucleoside analogs for patients with acute leukemias. Cancer Treat Rev. 2013 Dec;39(8):851-61. PMID: 23566572.

Jensen K, Johnson LA, Jacobson PA, et al. Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):519-25. PMID: 22249336.

Majda K, Lubecka K, Kaufman-Szymczyk A, et al. Clofarabine (2-chloro-2'-fluoro-2'-deoxyarabinosyladenine)--biochemical aspects of anticancer activity. Acta Pol Pharm. 2011 Jul-Aug;68(4):459-66. PMID: 21796927.

Aye Y, Stubbe J. Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9815-20. PMID: 21628579.

Parker WB, Shaddix SC, Chang CH, et al. Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Res. 1991 May 1;51(9):2386-94. PMID: 1707752.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L8277

    [Gln8]-Luteinizing Hormone Releasing Hormone, chicken

    Endogenous peptide hormone, involved in secreti...

    ≥95%
  • P2815

    Phenylbutyrate Sodium

    HDAC inhibitor.

    ≥98%
  • N3476

    Nitisinone

    Nitrobenzene; HPPD inhibitor.

    ≥99%
  • O4549

    Olmesartan Medoxomil

    AT1 inhibitor.

    ≥98%
  • O7992

    OTX-015

    BRD2/3/4 inhibitor.

    ≥98%
  • O7377

    Osthole

    O-methylated coumarin; Ca2+ channel blocker.

    ≥98%
  • S1606

    Secretin, porcine

    Endogenous peptide hormone, involved in water h...

    ≥95%
  • F4400

    Flag Peptide

    Peptide, used to tag proteins for affinity chro...

    ≥95%
  • D1759

    Deoxynivalenol

    Trichothecene mycotoxin produced by Fusarium.

    ≥98%, TLC
  • U0618

    Ubenimex

    Dipeptide; aminopeptidase (N/CD13) inhibitor.

    ≥98%
  • E7357

    Esomeprazole Potassium

    (S) isomer of omeprazole; H+/K+ ATPase and MAO-...

    ≥98%
  • O610292

    Ophiobolin B

    Naturally occurring sesteterpenoid.

    ≥98%
  • E6432

    (−)-Epinephrine

    Active isomer of epinephrine, endogenous hormon...

    ≥98%
  • Q8019

    Quetiapine Fumarate

    5-HT1A and σ1/2 agonist, 5-HT2A/2C/6/7, D1-4, ...

    ≥99%
  • F7657

    Ftorafur

    5-fluorouracil prodrug, pyrimidine analog; thym...

    ≥99%
  • E7579

    Estramustine Phosphate Disodium

    Nitrogen mustard and estradiol derivative; micr...

    ≥95%
  • U698578

    Urolithin C

    Ellagic acid derivative produced by gut microfl...

    ≥98%
  • D0260

    DAPT

    γ-Secretase inhibitor.

    ≥98%
  • A9818

    Azelastine Hydrochloride

    TRPV1 agonist, histamine H1 antagonist.

    ≥98%
  • V3252

    Vinorelbine Ditartrate

    Semi-synthetic vinca alkaloid from Catharanthus...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only