LKT Labs

Biochemicals for Life Science Research

Clozapine

Clozapine

Product ID C4757
Cas No. 5786-21-0
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $58.20 In stock
100 mg $97.20 In stock
250 mg $165.40 In stock
Bulk Quote

Quicklinks

Description

Clozapine is an atypical antipsychotic that also exhibits some immunosuppressive activity. Clozapine is clinically used to treat mood disorders. Clozapine binds Kv1.1 channels, prolonging the QT interval and also causes granulocytosis, limiting its clinical use. Clozapine acts as an antagonist at M1/2/3/5 muscarinic acetylcholine receptors (mAChRs) and D2 receptors, a partial agonist at 5-HT1A receptors, and as a full agonist at M4 mAChRs. Additionally, clozapine binds 5-HT2/3/6/7 receptors, D4 receptors, α1/2 adrenergic receptors, and histamine H1 receptors. Clozapine also potentiates GABAergic neurotransmission.

Product Info

Cas No.

5786-21-0
Purity

≥97%
Formula

C18H19ClN4
Formula Wt.

326.82
Chemical Name

8-chloro-11-(4-methyl-1-piperazinyl)-5H-Dibenzo(b,e)(1,4)diazepine

IUPAC Name

3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
Synonym

Clozaril, Leponex
Melting Point

183-184°C
Solubility

Soluble in DMSO or dilute aqueous acid.

Appearance

Yellow crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C4757 MSDS PDF
Info Sheet

C4757 Info Sheet PDF

References

Hill AP, Perrin MJ, Heide J, et al. Kinetics of drug interaction with the Kv11.1 potassium channel. Mol Pharmacol. 2014 May;85(5):769-76. PMID: 24586056.

Tanahashi S, Yamamura S, Nakagawa M, et al. Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes. Br J Pharmacol. 2012 Mar;165(5):1543-55. PMID: 21880034.

Wu Y, Blichowski M, Daskalakis ZJ, et al. Evidence that clozapine directly interacts on the GABAB receptor. Neuroreport. 2011 Sep 14;22(13):637-41. PMID: 21753741.

Nord M, Farde L. Antipsychotic occupancy of dopamine receptors in schizophrenia. CNS Neurosci Ther. 2011 Apr;17(2):97-103. PMID: 21143431.

Alvir JM, Lieberman JA, Safferman AZ, et al. Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N Engl J Med. 1993 Jul 15;329(3):162-7. PMID: 8515788.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D0261

    Dapivirine

    RT inhibitor.

    ≥98%
  • G1853

    Genipin

    Iridoid glycoside found in Gardinia jasminoides...

    ≥99%
  • A4803

    Amantadine Sulfate

    Viral M2 proton channel blocker, MAO-A, NET, NM...

    ≥98%
  • R3586

    Rivastigmine Tartrate

    AChE and BChE inhibitor.

    ≥99%
  • M0368

    Marbofloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • S1848

    Se-Methylseleno-L-cysteine

    Found in plants in Astragalus, Allium, and Bras...

    ≥98%
  • R0109

    Racecadotril

    Enkephalinase inhibitor.

    ≥98%
  • V9200

    VX-950

    NS3/4A serine protease inhibitor.

    ≥98%
  • T7034

    Trimethoprim

    Dihydrofolate reductase inhibitor.

    ≥98%
  • A5070

    Angiotensin Acetate

    Peptide, derivative of AT I, cleavage product o...

    ≥95%
  • G880000

    GW 405833

    Cannabinoid receptor 2 selective agonist.

    ≥98%
  • G2868

    Ghrelin, human

    Endogenous peptide hormone, involved in feeding...

    ≥98%
  • T0253

    Tangeretin

    Polymethoxy flavonoid found in citrus fruits.

    ≥98%
  • A0534

    Abiraterone

    Progesterone derivative; Cyp17A1 inhibitor.

    ≥99%
  • R5722

    Rofecoxib

    NSAID; COX-2 inhibitor.

    ≥98%
  • L1628

    Ac-LEHD-pNa

    Caspase 9 substrate.

    ≥95%
  • S0831

    S-(−)-Schisandrin B

    Found in Schisandra.

    ≥98%
  • F4501

    Flavanone

    Variety of flavonoid found in various plant sou...

    ≥98%
  • C0153

    Calcitonin, rat

    Endogenous neuropeptide hormone, lowers extrace...

    ≥95%
  • T6931

    Triclosan

    Diarylether; bacterial ENR binder, fatty acid s...

    ≥98%