• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Cortistatin-14

Cortistatin-14

Product ID C5773
Cas No. 186901-48-4
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $174.50 In stock
1 mg $306.70 In stock
2.5 mg $579.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cortistatin-14 is an endogenous neuropeptide related to somatostatin that binds and activates somatostatin and ghrelin receptors, inhibiting secretion of growth hormone and insulin. Cortistatin-14 exhibits anticonvulsant/antiepileptic, anti-inflammatory, and antinociceptive activities. In animal models, cortistatin-14 decreases seizure duration. In macrophages, this peptide inhibits production of IL-1β. Similarly, cortistatin-14 decreases capsaicin-induced release of CGRP in rat trachea and suppresses carrageenan-induced edema in other animal models.

Product Info

Cas No.

186901-48-4

Purity

≥95%

Formula

C81H113N19O19S2

Formula Wt.

1721.02

Synonym

CST-14, Cortistatin 14 (mouse, rat)

Solubility

Soluble in water.

Appearance

White to off-white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C5773 MSDS PDF

Info Sheet

C5773 Info Sheet PDF

References

Aourz N, Portelli J, Coppens J, et al. Cortistatin-14 Mediates its Anticonvulsant Effects Via sst2 and sst3 but Not Ghrelin Receptors. CNS Neurosci Ther. 2014 Mar 31. [Epub ahead of print]. PMID: 24685142.

Markovics A, Szoke É, Sándor K, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50. PMID: 21695504.

Broglio F, Arvat E, Benso A, et al. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. J Clin Endocrinol Metab. 2002 Aug;87(8):3783-90. PMID: 12161511.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P1754

    Penciclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • G5874

    Gossypol

    Polyphenol found in Gossypium; calcineurin and ...

    ≥98%
  • A6804

    Arbutin

    Glycoside hydroquinone originally found in Berg...

    ≥98%
  • L3374

    Lisinopril Dihydrate

    Enalapril analog; ACE inhibitor.

    ≥98%
  • B5074

    BMS-599626

    EGFR, VEGFR inhibitor.

    ≥98%
  • Z4833

    ZM-336372

    c-Raf inhibitor, tyrosine kinase inhibitor.

    ≥98%
  • T0105

    Taxol C

    Taxane synthesis intermediate.

    ≥95%
  • T2834

    Thiolutin

    Dithiolopyrrolone; RNA polymerase inhibitor.

    ≥98%
  • G7340

    GSK-126

    EZH2 HMT inhibitor.

    ≥98%, ≥99%ee
  • L1616

    LEE-011

    CDK4/6 inhibitor.

    ≥98%
  • M1826

    Meglumine

    Amino sugar, sorbitol derivative, used as a bul...

    ≥98%
  • A5235

    Amitriptyline Hydrochloride

    FIASMA, σ1, RyR2, TrkA/B agonist; SERT, NET in...

    ≥98%
  • O9256

    16-Oxocafestol

    Synthetic cafestol derivative.

    ≥97%
  • C0248

    Calcineurin Substrate

    Peptide used to measure in vitro calcineurin ac...

    ≥96%
  • A4777

    Altiratinib

    c-MET, Tie-2, VEGFR inhibitor.

    ≥98%
  • F4783

    Fluvoxamine Maleate

    FIASMA, 5-HT3 and σ1 agonist, SERT inhibitor.<...

    ≥97%
  • V0269

    Vardenafil Dihydrochloride

    PDE5 inhibitor.

    ≥99%
  • H9717

    Hydroxyzine Dihydrochloride

    FIASMA, histamine H1 inverse agonist, 5-HT2A, D...

    ≥98%
  • C4757

    Clozapine

    M4 mAChR agonist, 5-HT1A partial agonist, M1/2/...

    ≥97%
  • G5752

    Gonadorelin Acetate

    Synthetic peptide, GnRH derivative; GnRH agonist.
    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only