LKT Labs

Biochemicals for Life Science Research

Cromolyn Sodium

Cromolyn Sodium

Product ID C6955
Cas No. 15826-37-6
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $54.60 In stock
1 g $89.50 In stock
5 g $303.30 In stock
Bulk Quote

Quicklinks

Description

Cromolyn sodium is a mast cell stabilizer that prevents mast cell degranulation and histamine release. Cromolyn sodium may also inhibit transient receptor potential (TRP) channels on C fibers and act as an antagonist at Cl- channels. Cromolyn sodium activates phosphorylation of PKC and release of annexin A1, exhibiting anti-allergic, anti-asthma, and anti-inflammatory activities. This compound also inhibits release of pro-inflammatory cytokines. In animal models of myocarditis, cromolyn sodium displays cardioprotective benefit, preventing left ventricular remodeling and dysfunction.

Product Info

Cas No.

15826-37-6
Purity

≥99%
Formula

C23H14O11Na2
Formula Wt.

512.3
Chemical Name

5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium salt
IUPAC Name

disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4- oxochromene-2-carboxylate
Synonym

Cromolyn disodium salt, Aarane, Alerion, Allergocrom, Cromovet, Fivent, Inostral, Introl, Lomudal, Lomuspray, Nasmil, Opticrom, Rynacrom, Sofro, Vividrin
Melting Point

240-242°C
Solubility

Soluble in water.
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C6955 MSDS PDF
Info Sheet

C6955 Info Sheet PDF

References

Zhang A, Chi X, Luo G, et al. Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation. PLoS One. 2013 Oct 8;8(10):e75262. PMID: 24116032.

Yazid S, Sinniah A, Solito E, et al. Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1. PLoS One. 2013;8(3):e58963. PMID: 23527056.

Mina Y, Rinkevich-Shop S, Konen E, et al. Mast cell inhibition attenuates myocardial damage, adverse remodeling, and dysfunction during fulminant myocarditis in the rat. J Cardiovasc Pharmacol Ther. 2013 Mar;18(2):152-61. PMID: 23172937.

Yazid S, Leoni G, Getting SJ, et al. Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1718-24. PMID: 20558817.

Heinke S, Szücs G, Norris A, et al. Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br J Pharmacol. 1995 Aug;115(8):1393-8. PMID: 8564197.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • U682040

    URB597

    FAAH inhibitor.

    ≥98%
  • D0010

    3H-1,2-Dithiole-3-thione

    Induces activation of Nrf2; inhibits apoptosis ...

    ≥98%
  • C1621

    CEF4

    Peptide, vSrc-induced cytokine.

    ≥95%
  • F465817

    Flunisolide

    Corticosteroid

    ≥90%
  • E6993

    Erythromycin Resistance Peptide MRLFV

    Peptide, confers resistance against macrolide a...

    ≥95%
  • P200097

    PF-06821497

    EZH2 inhibitor

    ≥99%
  • P2817

    Phentolamine Hydrochloride

    ATP-sensitive K+ channel activator, α-adrenerg...

    ≥98%
  • A8812

    AWD 131-138

    GABA-A positive modulator.

    ≥99%
  • P2922

    Phenylhexyl Isothiocyanate

    ITC found in cruciferous vegetables; HDAC inhib...

    ≥98%
  • S6131

    N,N-Dimethyl-Sphingosine

    PP2A activator, Sphk1 and PKC inhibitor.

    ≥98%
  • A4935

    6-Aminocaproic Acid

    Protease inhibitor.

    ≥98%
  • T1006

    10-Acetoacetyl Paclitaxel

    Synthesis impurity

    ≥95%
  • A7604

    ATB 346

    NSAID; COX inhibitor and HS-releasing agent.

    ≥99%
  • C1869

    Cerulenin

    Found in Cephalosporium; fatty acid synthase in...

    ≥98%
  • L5749

    Lomefloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • L930280

    LXH254

    pan-RAF inhibitor

    ≥99%
  • P3568

    Pirarubicin

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥98%
  • L3453

    Linezolid

    Oxazolidinone; protein synthesis inhibitor.

    ≥99%
  • H9801

    Hyaluronic Acid Sodium (~1,000,000)

    Endogenous anionic non-sulfated glycosaminoglyc...
  • P0006

    Pituitary Adenylate Cyclase-activating Polypeptide (1-38), human, sheep, rat

    Endogenous peptide, involved in paracrine and a...

    ≥95%