Description
Cromolyn sodium is a mast cell stabilizer that prevents mast cell degranulation and histamine release. Cromolyn sodium may also inhibit transient receptor potential (TRP) channels on C fibers and act as an antagonist at Cl- channels. Cromolyn sodium activates phosphorylation of PKC and release of annexin A1, exhibiting anti-allergic, anti-asthma, and anti-inflammatory activities. This compound also inhibits release of pro-inflammatory cytokines. In animal models of myocarditis, cromolyn sodium displays cardioprotective benefit, preventing left ventricular remodeling and dysfunction.