Cromolyn Sodium

Name: Cromolyn Sodium
SKU: C6955
Availability: InStock

Product ID C6955

Cas No. 15826-37-6

Purity ≥99%

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Product Info
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Description

Cromolyn sodium is a mast cell stabilizer that prevents mast cell degranulation and histamine release. Cromolyn sodium may also inhibit transient receptor potential (TRP) channels on C fibers and act as an antagonist at Cl- channels. Cromolyn sodium activates phosphorylation of PKC and release of annexin A1, exhibiting anti-allergic, anti-asthma, and anti-inflammatory activities. This compound also inhibits release of pro-inflammatory cytokines. In animal models of myocarditis, cromolyn sodium displays cardioprotective benefit, preventing left ventricular remodeling and dysfunction.

Product Info

Cas No.	15826-37-6
Purity	≥99%
Formula	C₂₃H₁₄O₁₁Na₂
Formula Wt.	512.3
Chemical Name	5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium salt
IUPAC Name	disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4- oxochromene-2-carboxylate
Synonym	Cromolyn disodium salt, Aarane, Alerion, Allergocrom, Cromovet, Fivent, Inostral, Introl, Lomudal, Lomuspray, Nasmil, Opticrom, Rynacrom, Sofro, Vividrin
Melting Point	240-242°C
Solubility	Soluble in water.
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	C6955 MSDS PDF
Info Sheet	C6955 Info Sheet PDF

References

Zhang A, Chi X, Luo G, et al. Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation. PLoS One. 2013 Oct 8;8(10):e75262. PMID: 24116032.

Yazid S, Sinniah A, Solito E, et al. Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1. PLoS One. 2013;8(3):e58963. PMID: 23527056.

Mina Y, Rinkevich-Shop S, Konen E, et al. Mast cell inhibition attenuates myocardial damage, adverse remodeling, and dysfunction during fulminant myocarditis in the rat. J Cardiovasc Pharmacol Ther. 2013 Mar;18(2):152-61. PMID: 23172937.

Yazid S, Leoni G, Getting SJ, et al. Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1718-24. PMID: 20558817.

Heinke S, Szücs G, Norris A, et al. Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br J Pharmacol. 1995 Aug;115(8):1393-8. PMID: 8564197.