LKT Labs

Biochemicals for Life Science Research

Cromolyn Sodium

Cromolyn Sodium

Product ID C6955
Cas No. 15826-37-6
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $55.00 In stock
1 g $90.00 In stock
5 g $303.00 In stock
Bulk Quote

Quicklinks

Description

Cromolyn sodium is a mast cell stabilizer that prevents mast cell degranulation and histamine release. Cromolyn sodium may also inhibit transient receptor potential (TRP) channels on C fibers and act as an antagonist at Cl- channels. Cromolyn sodium activates phosphorylation of PKC and release of annexin A1, exhibiting anti-allergic, anti-asthma, and anti-inflammatory activities. This compound also inhibits release of pro-inflammatory cytokines. In animal models of myocarditis, cromolyn sodium displays cardioprotective benefit, preventing left ventricular remodeling and dysfunction.

Product Info

Cas No.

15826-37-6
Purity

≥99%
Formula

C23H14O11Na2
Formula Wt.

512.3
Chemical Name

5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium salt
IUPAC Name

disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4- oxochromene-2-carboxylate
Synonym

Cromolyn disodium salt, Aarane, Alerion, Allergocrom, Cromovet, Fivent, Inostral, Introl, Lomudal, Lomuspray, Nasmil, Opticrom, Rynacrom, Sofro, Vividrin
Melting Point

240-242°C
Solubility

Soluble in water.
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C6955 MSDS PDF
Info Sheet

C6955 Info Sheet PDF

References

Zhang A, Chi X, Luo G, et al. Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation. PLoS One. 2013 Oct 8;8(10):e75262. PMID: 24116032.

Yazid S, Sinniah A, Solito E, et al. Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1. PLoS One. 2013;8(3):e58963. PMID: 23527056.

Mina Y, Rinkevich-Shop S, Konen E, et al. Mast cell inhibition attenuates myocardial damage, adverse remodeling, and dysfunction during fulminant myocarditis in the rat. J Cardiovasc Pharmacol Ther. 2013 Mar;18(2):152-61. PMID: 23172937.

Yazid S, Leoni G, Getting SJ, et al. Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1718-24. PMID: 20558817.

Heinke S, Szücs G, Norris A, et al. Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br J Pharmacol. 1995 Aug;115(8):1393-8. PMID: 8564197.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T1656

    Tenoxicam Impurity B

    Tenoxicam impurity

    ≥98%
  • D3330

    Dihydrotanshinone

    Found in Salvia; fatty acid synthase and AChE i...

    ≥90%
  • D564088

    10-Acetyl Docetaxel

    Docetaxel impurity

    ≥98%
  • C5870

    Corosolic Acid

    Pentacyclic triterpene found in the Banaba plan...

    ≥98%
  • M1566

    (+)-S-Methyl-L-cysteine-S-oxide

    Alliin analog found in cruciferous vegetables.<...

    ≥98%
  • C0245

    Calcitonin Gene Related Peptide, rat

    Endogenous calcitonin-family peptide, involved ...

    ≥95%
  • W5726

    Wogonin

    Flavonoid found in Scutellaria; CDK9 inhibitor....

    ≥98%
  • G062680

    GBR-12909 Dihydrochloride

    Dopamine reuptake inhibitor (DRI).

    ≥98%
  • S5869

    Sorafenib Tosylate

    c-Raf, RET, VEGFR1 inhibitor, potential HMT inh...

    ≥99%
  • K977545

    Kynurenic acid

    Endogenous NMDA receptor antagonist.

    ≥99%
  • O7053

    L-Ornithine Hydrochloride

    Non-proteinogenic amino acid, L-arginine metabo...

    ≥98%
  • C8070

    Curcumin, high purity

    Active compound found in turmeric; MST1 activat...

    ≥98%
  • M1752

    Men 10376

    Peptide; NK2 antagonist.

    ≥95%
  • A2056

    Aflatoxin Q1

    Mycotoxin metabolite

    ≥98%
  • C4556

    Clofibric Acid

    Metabolite of clofibrate; PPARα agonist.

    ≥98%
  • A6933

    Aristolochic Acid B

    Found in Aristolochia and Radix; potential PLA2...

    ≥95%
  • R5773

    Rosiglitazone

    Thiazolidinedione; PPARγ agonist.

    ≥99%
  • T3585

    Tivozanib

    VEGFR1/2/3, c-Kit, PDGFR inhibitor.

    ≥98%
  • L1628

    Ac-LEHD-pNa

    Caspase 9 substrate.

    ≥95%
  • N0263

    Naphazoline Nitrate

    α1-adrenergic agonist.

    ≥97%