LKT Labs

Biochemicals for Life Science Research

Cromolyn Sodium

Cromolyn Sodium

Product ID C6955
Cas No. 15826-37-6
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $55.00 In stock
1 g $90.00 In stock
5 g $303.00 In stock
Bulk Quote

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Description

Cromolyn sodium is a mast cell stabilizer that prevents mast cell degranulation and histamine release. Cromolyn sodium may also inhibit transient receptor potential (TRP) channels on C fibers and act as an antagonist at Cl- channels. Cromolyn sodium activates phosphorylation of PKC and release of annexin A1, exhibiting anti-allergic, anti-asthma, and anti-inflammatory activities. This compound also inhibits release of pro-inflammatory cytokines. In animal models of myocarditis, cromolyn sodium displays cardioprotective benefit, preventing left ventricular remodeling and dysfunction.

Product Info

Cas No.

15826-37-6
Purity

≥99%
Formula

C23H14O11Na2
Formula Wt.

512.3
Chemical Name

5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium salt
IUPAC Name

disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4- oxochromene-2-carboxylate
Synonym

Cromolyn disodium salt, Aarane, Alerion, Allergocrom, Cromovet, Fivent, Inostral, Introl, Lomudal, Lomuspray, Nasmil, Opticrom, Rynacrom, Sofro, Vividrin
Melting Point

240-242°C
Solubility

Soluble in water.
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C6955 MSDS PDF
Info Sheet

C6955 Info Sheet PDF

References

Zhang A, Chi X, Luo G, et al. Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation. PLoS One. 2013 Oct 8;8(10):e75262. PMID: 24116032.

Yazid S, Sinniah A, Solito E, et al. Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1. PLoS One. 2013;8(3):e58963. PMID: 23527056.

Mina Y, Rinkevich-Shop S, Konen E, et al. Mast cell inhibition attenuates myocardial damage, adverse remodeling, and dysfunction during fulminant myocarditis in the rat. J Cardiovasc Pharmacol Ther. 2013 Mar;18(2):152-61. PMID: 23172937.

Yazid S, Leoni G, Getting SJ, et al. Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1718-24. PMID: 20558817.

Heinke S, Szücs G, Norris A, et al. Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br J Pharmacol. 1995 Aug;115(8):1393-8. PMID: 8564197.

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