• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Cyclopamine

Cyclopamine

Product ID C9710
Cas No. 4449-51-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $85.20 In stock
25 mg $170.00 In stock
100 mg $472.60 In stock
500 mg $1,700.50 Please Inquire
1 g $2,764.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cyclopamine is a steroidal jerveratrum alkaloid found in Veratrum that binds Smo, inhibiting hedgehog (Shh) signaling pathways. Cyclopamine exhibits anticancer activity, decreases expression of Gli2 and Bcl-2, inhibiting proliferation and inducing apoptosis in adenoma cells and neuroblastoma cells.

CYCLOPAMINE SOLUBILITY: Ethanol is the best cyclopamine solvent for biological use.  A 2.8% solution (28 mg/mL) can be prepared by sonicating the cyclopamine in ethanol. Avoid over heating. Storage at -20 ºC is recommended. If cyclopamine crystallizes out of solution:  upon thawing, the mixture can be heated or sonicated again to redissolve the cyclopamine.
Methanol and DMSO can also be used as cyclopamine solvents, but solubility in methanol is much less (0.7 mg/mL).  Substantial heating is again needed to achieve solution with methanol or DMSO.

Product Info

Cas No.

4449-51-8

Purity

≥98%

Formula

C27H41NO2

Formula Wt.

411.62

Chemical Name

Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)pyridin)-3- ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b- octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-

IUPAC Name

(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10, 11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11, 11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7, 7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol

Synonym

11-Deoxyjervine, 11-Deoxojervine, HSDB 3505.

Melting Point

212-215°C

Solubility

Soluble in ethanol (≥20 mg/mL, methanol (0.7 mg/mL). Soluble in DMSO & insoluble in water.

Appearance

White Crystalline Solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C9710 MSDS PDF

Info Sheet

C9710 Info Sheet PDF

Brochures

Cyclopamine Flyer

Hedgehog Signaling Flyer

WNT Booklet

References

Song M, Ou X, Xiao C, et al. Hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing Gli2 and Bcl2 expression in human salivary pleomorphic adenoma cells. Biomed Rep. 2013 Mar;1(2):325-329. PMID: 24648943.

Xu L, Wang X, Wan J, et al. Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth. Mol Cell Biochem. 2012 May;364(1-2):235-41. PMID: 22350753.

Stanton BZ, Peng LF. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst. 2010 Jan;6(1):44-54. PMID: 20024066.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P1761

    Pepstatin

    Aspartyl protease inhibitor.

    ≥98%
  • B0246

    Balofloxacin Dihydrate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • F1670

    Ferulic Acid Methyl Ester

    Hydroxycinnamic aicd, verbascoside metabolite, ...

    ≥98%
  • O938565

    6-Oxodocetaxel

    Docetaxel impurity

    ≥98%
  • Q8019

    Quetiapine Fumarate

    5-HT1A and σ1/2 agonist, 5-HT2A/2C/6/7, D1-4, ...

    ≥99%
  • A5219

    Anethole Trithione

    Oltipraz analog, salivary gland secretion enhan...

    ≥98%
  • L1878

    Letrozole

    Aromatase inhibitor.

    ≥98%
  • A5044

    Amlodipine Besylate

    Dihydropyridine, FIASMA; L-type Ca2+ channel bl...

    ≥98%
  • N8760

    NVP-TAE684

    ALK, c-Fes, LRRK2 inhibitor.

    ≥98%
  • G4480

    Glucagon, human

    Endogenous peptide hormone, counteracts insulin...

    ≥95%
  • G3558

    20R-Ginsenoside Rh2

    Triterpene saponin found in Panax.

    ≥98%
  • G0179

    Gastrin-1, rat

    Endogenous peptide hormone; CCK2 agonist, indir...

    ≥95%
  • S0045

    Salbutamol Sulfate

    β2-adrenergic agonist.

    ≥98%
  • T1750

    Temocapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • G3459

    Ginsenoside Rg2

    Triterpene saponin found in species of Panax.

    ≥98%
  • P6954

    Pioglitazone Hydrochloride

    Thiazolidinedione; PPARα/γ agonist, mitoNEET ...

    ≥98%
  • A4617

    Aloe Emodin

    Anthraquinone found in aloe; CTFR Cl- channel a...

    ≥98%
  • V9202

    VX-702

    p38 MAPK inhibitor.

    ≥98%
  • P0218

    Paeoniflorin

    Found in Paeonia; L-type Ca2+ channel blocker.<...

    ≥98%
  • I5414

    Indapamide

    Thiazide-like diuretic; Kv7.1 and minK K+ chann...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only