LKT Labs

Biochemicals for Life Science Research

Cyclovirobuxine D

Cyclovirobuxine D

Product ID C9711
Cas No. 860-79-7
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $128.00 In stock
100 mg $318.00 In stock
500 mg $1,086.00 In stock
Bulk Quote

Quicklinks

Description

Cyclovirobuxine D is originally found in Buxus and displays cardioprotective and anticancer activities. Cyclovirobuxine inhibits the viability of breast cancer cells, inhibiting phosphorylation of Akt and mTOR and inducing autophagy. This compound also shows benefit in the treatment of heart failure but may prolong the QT interval through inhibition of human ether-a-go-go-related (hERG) K+ channel currents. Additionally, cyclovirobuxine D decreases infarct size and venous thrombus size in animal models of myocardial ischemia.

Product Info

Cas No.

860-79-7
Purity

≥97%
Formula

C26H46N2O
Formula Wt.

402.66
IUPAC Name

C26H46N2O
Synonym

Bebuxine, Cyclovirobuxine
Melting Point

219-224°C
Appearance

White crystal

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9711 MSDS PDF
Info Sheet

C9711 Info Sheet PDF

References

Lu J, Sun D, Gao S, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. PMID: 24758922.

Yu B, Fang TH, Lü GH, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77. PMID: 21575690.

Zhao J, Wang Q, Xu J, et al. Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells. Eur J Pharmacol. 2011 Jun 25;660(2-3):259-67. PMID: 21497594.

Hu D, Liu X, Wang Y, et al. Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. Eur J Pharmacol. 2007 Aug 13;569(1-2):103-9. PMID: 17555743.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E6396

    EPZ005687

    EZH2 HMT inhibitor.

    ≥99%
  • M324083

    Micafungin

    Echinocandin

    ≥95%
  • A2658

    Agomelatine

    Melatonin analog; MT1/2 agonist, 5-HT2C antagon...

    ≥98%
  • S6131

    N,N-Dimethyl-Sphingosine

    PP2A activator, Sphk1 and PKC inhibitor.

    ≥98%
  • R3010

    Recombinant Tp-chimeric protein

    Recombinant chimeric protein containing Trepone...

    ≥95%
  • C1176

    CCT-128930

    Pyrrolopyrimidine; Akt inhibitor.

    ≥98%
  • E537335

    Enniatin B1

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • F4581

    5-Fluorocytosine

    Synthetic antifungal.

    ≥98%
  • G0000

    G250.A2 Peptide

    Peptide, carbonic anhydrase G250 epitope.

    ≥95%
  • O9256

    16-Oxocafestol

    Synthetic cafestol derivative.

    ≥97%
  • G4581

    Glucosamine Sulfate Potassium Chloride

    Endogenous amino acid sugar involved in cartila...

    ≥98%
  • T0102

    7-epi-Taxol

    Taxane found in Taxus; potential microtubule de...

    ≥95%
  • I1400

    Idarubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥98%
  • T9969

    Tyrphostin AG490

    JAK2 inhibitor, potential EGFR inhibitor.

    ≥98%
  • H9620

    7-Hydroxyaristolochic Acid A

    Derivative of aristolochic acid found in Asarum...

    ≥95%
  • A5162

    Amprolium Hydrochloride

    Thiamine, coccidiostat; thiamine transporter in...

    ≥97%
  • H1672

    Hesperetin

    Flavanone found in species of Citrus; L-type Ca...

    ≥97%
  • F0275

    Fasudil Hydrochloride

    ROCK inhibitor.

    ≥98%
  • K0276

    Katacalcin

    Peptide found in crustaceans; PKA activator.

    ≥95%
  • M1626

    Megestrol Acetate

    Synthetic progestogen, orexigenic.

    ≥98%