LKT Labs

Biochemicals for Life Science Research

Cyclovirobuxine D

Cyclovirobuxine D

Product ID C9711
Cas No. 860-79-7
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $128.00 In stock
100 mg $318.00 In stock
500 mg $1,086.00 In stock
Bulk Quote

Quicklinks

Description

Cyclovirobuxine D is originally found in Buxus and displays cardioprotective and anticancer activities. Cyclovirobuxine inhibits the viability of breast cancer cells, inhibiting phosphorylation of Akt and mTOR and inducing autophagy. This compound also shows benefit in the treatment of heart failure but may prolong the QT interval through inhibition of human ether-a-go-go-related (hERG) K+ channel currents. Additionally, cyclovirobuxine D decreases infarct size and venous thrombus size in animal models of myocardial ischemia.

Product Info

Cas No.

860-79-7
Purity

≥97%
Formula

C26H46N2O
Formula Wt.

402.66
IUPAC Name

C26H46N2O
Synonym

Bebuxine, Cyclovirobuxine
Melting Point

219-224°C
Appearance

White crystal

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9711 MSDS PDF
Info Sheet

C9711 Info Sheet PDF

References

Lu J, Sun D, Gao S, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. PMID: 24758922.

Yu B, Fang TH, Lü GH, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77. PMID: 21575690.

Zhao J, Wang Q, Xu J, et al. Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells. Eur J Pharmacol. 2011 Jun 25;660(2-3):259-67. PMID: 21497594.

Hu D, Liu X, Wang Y, et al. Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. Eur J Pharmacol. 2007 Aug 13;569(1-2):103-9. PMID: 17555743.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M9646

    Myelin Basic Protein (68-82), guinea pig

    Immunodominant peptide epitope occurring in mul...

    ≥95%
  • A724092

    Asciminib Hydrochloride

    Allosteric inhibitor

    ≥98%
  • P3210

    Picoplatin

    Pt-based DNA cross-linker.

    ≥98%
  • S1607

    Secretin, rat

    Endogenous peptide hormone, involved in feeding...

    ≥95%
  • S1872

    Sesamin

    Lignin found in Sesamin indicum;

    ≥98%
  • L3453

    Linezolid

    Oxazolidinone; protein synthesis inhibitor.

    ≥99%
  • O4531

    Oligomycin A

    Macrolide; F1F0 ATP synthase inhibitor.

    ≥97%, TLC, HPLC
  • L1735

    Levitide

    Antimicrobial peptide found in amphibians.

    ≥95%
  • M400005

    MK-5108 Hydrochloride

    Aurora kinase A inhibitor.

    ≥98%
  • C4417

    Clemizole

    TRPC5 activator, NS4B and histamine H1 inhibito...

    ≥98%
  • E5217

    β-Endorphin, human

    Endogenous opioid peptide; μOR agonist.

    ≥95%
  • T1002

    2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate)

    Synthesis intermediate

    ≥95%
  • H9863

    Hyperforin Dicyclohexylammonium

    Stable salt form of hyperforin, a compound foun...

    ≥97%
  • D3202

    Diallyl Trisulfide

    Organosulfur found in garlic.

    ≥98%
  • W317520

    WIN 55,212-2 Mesylate

    Non-selective cannabinoid receptor agonist.

    ≥98%
  • I7557

    1-Isothiocyanato-6-(methylsulfonyl)-hexane

    Synthetic ITC, erysolin analog.

    ≥98%
  • M4102

    MK-1775

    Wee1 inhibitor.

    ≥98%
  • M1685

    Mevastatin

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • C0374

    β-Casomorphin, human

    Peptide, casein fragment.

    ≥95%
  • L1782

    Levodopa

    Endogenous catecholamine precursor, also found ...

    ≥98%