LKT Labs

Biochemicals for Life Science Research

Cyclovirobuxine D

Cyclovirobuxine D

Product ID C9711
Cas No. 860-79-7
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $128.00 In stock
100 mg $318.00 In stock
500 mg $1,086.00 In stock
Bulk Quote

Quicklinks

Description

Cyclovirobuxine D is originally found in Buxus and displays cardioprotective and anticancer activities. Cyclovirobuxine inhibits the viability of breast cancer cells, inhibiting phosphorylation of Akt and mTOR and inducing autophagy. This compound also shows benefit in the treatment of heart failure but may prolong the QT interval through inhibition of human ether-a-go-go-related (hERG) K+ channel currents. Additionally, cyclovirobuxine D decreases infarct size and venous thrombus size in animal models of myocardial ischemia.

Product Info

Cas No.

860-79-7
Purity

≥97%
Formula

C26H46N2O
Formula Wt.

402.66
IUPAC Name

C26H46N2O
Synonym

Bebuxine, Cyclovirobuxine
Melting Point

219-224°C
Appearance

White crystal

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9711 MSDS PDF
Info Sheet

C9711 Info Sheet PDF

References

Lu J, Sun D, Gao S, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. PMID: 24758922.

Yu B, Fang TH, Lü GH, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77. PMID: 21575690.

Zhao J, Wang Q, Xu J, et al. Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells. Eur J Pharmacol. 2011 Jun 25;660(2-3):259-67. PMID: 21497594.

Hu D, Liu X, Wang Y, et al. Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. Eur J Pharmacol. 2007 Aug 13;569(1-2):103-9. PMID: 17555743.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5281

    Angiotensin II (4-8), human

    Endogenous peptide fragment, involved in vasoco...

    ≥95%
  • M1676

    Methotrexate Hydrate

    DHF reductase inhibitor.

    ≥98%
  • M5675

    Motilin, canine

    Endogenous peptide hormone; motilin agonist.

    ≥95%
  • A5228

    Angiogenin

    Small protein, cleaves RNA.

    ≥98%
  • E0073

    Ebselen

    Synthetic glutathione peroxidase mimetic; yeast...

    ≥99%
  • E6896

    Erysolin

    ITC found in cruciferous vegetables, analog of ...

    ≥97%
  • C600000

    CP 55940

    Non-selective CB receptor agonist.

    ≥97%
  • G346851

    Givinostat Hydrochloride

    Non-selective HDAC inhibitor.

    ≥98%
  • G2969

    Growth Hormone Releasing Hexapeptide

    Synthetic peptide hormone, met-enkephalin analo...

    ≥95%
  • G4434

    Gliotoxin

    Toxin produced by Aspergillus.

    ≥98%
  • P200099

    PF-06939999

    PRMT5 inhibitor

    ≥98%
  • Q8016

    Quercetin Dihydrate

    Flavonoid found in fruits, vegetables, and grai...

    ≥95%
  • T0107

    Xylosyltaxol C

    Taxane found in species of Taxus; potential mic...

    ≥90%
  • F4502

    Flavokawain A

    Chalcone kavalactone found in Piper methysticum...

    ≥98%
  • N1979

    Neuromedin

    Endogenous proneurotensin peptide, involved in ...

    ≥95%
  • M7528

    α-Melanocyte Stimulating Hormone

    Endogenous peptide hormone derived from POMC, i...

    ≥98%
  • A2054

    Aflatoxin M2

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • A5033

    4-Aminosalicylic Acid

    Dihydrofolate reductase inhibitor.

    ≥98%
  • B0026

    Bafilomycin B1

    Macrolide; vacuolar H+-ATPase inhibitor.

    ≥97%
  • L9800

    LY-364947

    ALK5 (activin-like) inhibitor.

    ≥98%