LKT Labs

Biochemicals for Life Science Research

Cyclovirobuxine D

Cyclovirobuxine D

Product ID C9711
Cas No. 860-79-7
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $127.60 In stock
100 mg $317.50 In stock
500 mg $1,086.00 In stock
Bulk Quote

Quicklinks

Description

Cyclovirobuxine D is originally found in Buxus and displays cardioprotective and anticancer activities. Cyclovirobuxine inhibits the viability of breast cancer cells, inhibiting phosphorylation of Akt and mTOR and inducing autophagy. This compound also shows benefit in the treatment of heart failure but may prolong the QT interval through inhibition of human ether-a-go-go-related (hERG) K+ channel currents. Additionally, cyclovirobuxine D decreases infarct size and venous thrombus size in animal models of myocardial ischemia.

Product Info

Cas No.

860-79-7
Purity

≥97%
Formula

C26H46N2O
Formula Wt.

402.66
IUPAC Name

C26H46N2O
Synonym

Bebuxine, Cyclovirobuxine
Melting Point

219-224°C
Appearance

White crystal

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9711 MSDS PDF
Info Sheet

C9711 Info Sheet PDF

References

Lu J, Sun D, Gao S, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. PMID: 24758922.

Yu B, Fang TH, Lü GH, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77. PMID: 21575690.

Zhao J, Wang Q, Xu J, et al. Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells. Eur J Pharmacol. 2011 Jun 25;660(2-3):259-67. PMID: 21497594.

Hu D, Liu X, Wang Y, et al. Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. Eur J Pharmacol. 2007 Aug 13;569(1-2):103-9. PMID: 17555743.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A4854

    β-Amyloid Peptide (1-42), rat

    Endogenous APP peptide cleavage product, primar...

    ≥95%
  • E7758

    Etomidate

    GABA-A agonist.

    ≥99%
  • C1650

    β-Cembrenediol Methyl Ether

    Diterpene found in tobacco plants and cigarette...

    ≥98%
  • X4402

    XL-147

    Dual inhibitor of PI3K and mTOR.

    ≥98%
  • D582705

    Dorsomorphin Dihydrochloride

    Inhibitor of ALK2, ALK3, ALK6, and AMPK.

    ≥98%
  • O9596

    Oxybutynin Hydrochloride

    mAChR antagonist.  
    ≥98%
  • F4556

    Florfenicol

    Synthetic fluorinated thiamphenicol analog; pro...

    ≥98%
  • A1330

    Adipokinetic Hormone

    Neuropeptide hormone found in insects, involved...

    ≥95%
  • B564086

    Boceprevir

    Inhibits HCV replication

    ≥98%
  • S1843

    L-Selectin

    Endogenous adhesion molecule, binds PKC, calmod...

    ≥95%
  • M7200

    MS436

    BRD4 inhibitor.

    ≥99%
  • H1662

    HER2/neu (654-662) GP2

    Peptide fragment of HER2/neu/erbB2 receptor.

    ≥95%
  • A488246

    AMG-232

    MDM2-p53 inhibitor

    ≥99%
  • M576486

    Mometasone Furoate

    Synthetic glucocorticoid

    ≥98%
  • A1318

    Adenine

    Endogenous purine nucleotide base, required for...

    ≥98%
  • M3476

    Mithramycin

    Polyketide; DNMT 1 inhibitor, RNA synthesis inh...

    ≥98%
  • P6852

    Propafenone Hydrochloride

    β-adrenergic antagonist, Kv1.4 and K2P2 K+ cha...

    ≥98%
  • V3277

    Vitamin E

    Synthetic vitamin E, antioxidant.

    ≥98%
  • A0822

    N-Acetyl-S-(N-methylsulfinylbutylthiocarbamoyl)-L-cysteine

    Sulforaphane-cysteine conjugate.

    ≥98%
  • O5212

    Ondansetron Hydrochloride Dihydrate

    5-HT3 antagonist.

    ≥98%