LKT Labs

Biochemicals for Life Science Research

Cyclovirobuxine D

Cyclovirobuxine D

Product ID C9711
Cas No. 860-79-7
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $128.00 In stock
100 mg $318.00 In stock
500 mg $1,086.00 In stock
Bulk Quote

Quicklinks

Description

Cyclovirobuxine D is originally found in Buxus and displays cardioprotective and anticancer activities. Cyclovirobuxine inhibits the viability of breast cancer cells, inhibiting phosphorylation of Akt and mTOR and inducing autophagy. This compound also shows benefit in the treatment of heart failure but may prolong the QT interval through inhibition of human ether-a-go-go-related (hERG) K+ channel currents. Additionally, cyclovirobuxine D decreases infarct size and venous thrombus size in animal models of myocardial ischemia.

Product Info

Cas No.

860-79-7
Purity

≥97%
Formula

C26H46N2O
Formula Wt.

402.66
IUPAC Name

C26H46N2O
Synonym

Bebuxine, Cyclovirobuxine
Melting Point

219-224°C
Appearance

White crystal

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9711 MSDS PDF
Info Sheet

C9711 Info Sheet PDF

References

Lu J, Sun D, Gao S, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. PMID: 24758922.

Yu B, Fang TH, Lü GH, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77. PMID: 21575690.

Zhao J, Wang Q, Xu J, et al. Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells. Eur J Pharmacol. 2011 Jun 25;660(2-3):259-67. PMID: 21497594.

Hu D, Liu X, Wang Y, et al. Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. Eur J Pharmacol. 2007 Aug 13;569(1-2):103-9. PMID: 17555743.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • Y0002

    Y-320

    Phenylpyrazoleanilide; IL-17 production inhibit...

    ≥98%
  • B1973

    Besifloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • P0218

    Paeoniflorin

    Found in Paeonia; L-type Ca2+ channel blocker.<...

    ≥98%
  • E325127

    EIDD-1931

    Broad-spectrum antiviral activity against SARS-...

    ≥99%
  • B0245

    Balicatib

    Cathepsin K inhibitor.

    ≥98%
  • A5160

    Ampicillin Trihydrate

    β-lactam; transpeptidase inhibitor.

    ≥97%
  • N1987

    Neuropeptide Y (13-36), human

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • R2810

    Recombinant Multi-epitope Chimeric HIV Antigen 1

    Recombinant HIV-1 multi-epitope chimeric antige...

    ≥95%
  • A4679

    Altrenogest

    Synthetic progestogen; PR agonist.

    ≥98%
  • T1778

    2,3,5,6-Tetramethylpyrazine

    Dihydropyrazine found in Ligusticum walliichi. ...

    ≥98%
  • T286165

    Theaflavin-3-gallate

    Polyphenolic compound present in black tea.

    ≥95%
  • S7970

    Strontium Ranelate

    Bone deterioration inhibitor, potential CaR ago...

    ≥98%
  • T1672

    Terbinafine Hydrochloride

    Allylamine; squalene oxidase and KSR1 inhibitor...

    ≥98%
  • A9813

    AZD-8931

    Inhibitor of EGFR, HER2, and HER3.

    ≥98%
  • N1978

    Neurokinin B

    Neuromodulator, biomarker

    ≥95%
  • E7324

    Ethisterone

    Synthetic steroid hormone, contraceptive; PR ag...

    ≥98%
  • R5773

    Rosiglitazone

    Thiazolidinedione; PPARγ agonist.

    ≥99%
  • P6002

    PP-121

    p110α PI3K, DNA-PK, mTOR, Abl, Hck, Src, VEGFR...

    ≥98%
  • M568266

    Mogroside IIIe

    Triterpenoid

    ≥98%
  • H9612

    Hydrocortisone 21-Acetate

    Steroid hormone involved in stress signaling; g...

    ≥98%