LKT Labs

Biochemicals for Life Science Research

Cyclovirobuxine D

Cyclovirobuxine D

Product ID C9711
Cas No. 860-79-7
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $128.00 In stock
100 mg $318.00 In stock
500 mg $1,086.00 In stock
Bulk Quote

Quicklinks

Description

Cyclovirobuxine D is originally found in Buxus and displays cardioprotective and anticancer activities. Cyclovirobuxine inhibits the viability of breast cancer cells, inhibiting phosphorylation of Akt and mTOR and inducing autophagy. This compound also shows benefit in the treatment of heart failure but may prolong the QT interval through inhibition of human ether-a-go-go-related (hERG) K+ channel currents. Additionally, cyclovirobuxine D decreases infarct size and venous thrombus size in animal models of myocardial ischemia.

Product Info

Cas No.

860-79-7
Purity

≥97%
Formula

C26H46N2O
Formula Wt.

402.66
IUPAC Name

C26H46N2O
Synonym

Bebuxine, Cyclovirobuxine
Melting Point

219-224°C
Appearance

White crystal

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9711 MSDS PDF
Info Sheet

C9711 Info Sheet PDF

References

Lu J, Sun D, Gao S, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. PMID: 24758922.

Yu B, Fang TH, Lü GH, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77. PMID: 21575690.

Zhao J, Wang Q, Xu J, et al. Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells. Eur J Pharmacol. 2011 Jun 25;660(2-3):259-67. PMID: 21497594.

Hu D, Liu X, Wang Y, et al. Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. Eur J Pharmacol. 2007 Aug 13;569(1-2):103-9. PMID: 17555743.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C2947

    Chlorpromazine Hydrochloride

    Phenothiazine, FIASMA; D1/2/3/4, 5-HT1/2, M1/2 ...

    ≥98%
  • T4400

    TL-32711

    Smac mimetic; IAP inhibitor.

    ≥98%
  • L960006

    LY-2606368

    CHK1 inhibitor.

    ≥98%
  • P0297

    Paroxetine Hydrochloride Hemihydrate

    FIASMA, SERT and NET inhibitor, mAChR antagonis...

    ≥98%
  • A5378

    Antimycin A

    Oxidative phosphorylation inhibitor.
  • O4578

    Oltipraz

    Antioxidant; Nrf2 activator.

    ≥98%
  • D1628

    5,6-Dehydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • A7461

    Asperosaponin VI

    Triterpene saponin found in Dipsacus asper.

    ≥98%
  • I7458

    1-Isothiocyanato-9-(methylsulfinyl)-nonane

    ITC, sulforaphane analog.

    ≥98%
  • A016495

    5-Aminopyrimidine

    Building block

    ≥98%
  • N1983

    Neuropeptide Y (3-36), human

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • T0081

    Taurine

    Endogenous sulfonic acid involved in Ca2+ signa...

    ≥99%
  • D8014

    DU-14

    Steroid sulfatase inhibitor.

    ≥98%
  • S3476

    Sitagliptin Phosphate Monohydrate

    DPP4 inhibitor.

    ≥98%
  • N4974

    NMS-E628

    ALK and Ros1 inhibitor, Trk antagonist.

    ≥98%
  • L589921

    Loxapine Succinate

    D2 and D4 dopamine receptor inhibitor.

    ≥99%
  • C9882

    Cytochalasin E

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • T0115

    Taxol Side Chain Acid

    Side chain commonly attached to taxanes.

    ≥98%
  • C0261

    Captopril

    ACE inhibitor.

    ≥98%
  • S8047

    R,S-Sulforaphane, Research Grade

    Synthetic ITC.

    ≥97%