LKT Labs

Biochemicals for Life Science Research

Cyclovirobuxine D

Cyclovirobuxine D

Product ID C9711
Cas No. 860-79-7
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $127.60 In stock
100 mg $317.50 In stock
500 mg $1,086.00 In stock
Bulk Quote

Quicklinks

Description

Cyclovirobuxine D is originally found in Buxus and displays cardioprotective and anticancer activities. Cyclovirobuxine inhibits the viability of breast cancer cells, inhibiting phosphorylation of Akt and mTOR and inducing autophagy. This compound also shows benefit in the treatment of heart failure but may prolong the QT interval through inhibition of human ether-a-go-go-related (hERG) K+ channel currents. Additionally, cyclovirobuxine D decreases infarct size and venous thrombus size in animal models of myocardial ischemia.

Product Info

Cas No.

860-79-7
Purity

≥97%
Formula

C26H46N2O
Formula Wt.

402.66
IUPAC Name

C26H46N2O
Synonym

Bebuxine, Cyclovirobuxine
Melting Point

219-224°C
Appearance

White crystal

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9711 MSDS PDF
Info Sheet

C9711 Info Sheet PDF

References

Lu J, Sun D, Gao S, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. PMID: 24758922.

Yu B, Fang TH, Lü GH, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77. PMID: 21575690.

Zhao J, Wang Q, Xu J, et al. Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells. Eur J Pharmacol. 2011 Jun 25;660(2-3):259-67. PMID: 21497594.

Hu D, Liu X, Wang Y, et al. Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. Eur J Pharmacol. 2007 Aug 13;569(1-2):103-9. PMID: 17555743.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E7657

    Etoposide

    Podophyllotoxin derivative; topoisomerase II in...

    ≥98%
  • P2303

    Phallacidin

    Phallotoxin found in Amanita phalloides; microt...

    ≥98%
  • B1769

    Bergenin

    Trihydroxybenzoic acid glycoside found in Berge...

    ≥98%
  • S1060

    Small Cardioactive Peptide A

    Peptide found in molluscs, cardiomodulator.

    ≥95%
  • O7377

    Osthole

    O-methylated coumarin; Ca2+ channel blocker.

    ≥98%
  • H9620

    7-Hydroxyaristolochic Acid A

    Derivative of aristolochic acid found in Asarum...

    ≥95%
  • I5830

    Iohexol

    Low osmolarity contrast agent used for imaging ...

    ≥98%
  • E2258

    Efonidipine Hydrochloride

    Calcium channel blocker.

    ≥98%
  • E5057

    Emodin

    Anthraquinone found in various plant sources; C...

    ≥95%
  • D3221

    Difluoromethylornithine Hydrochloride Monohydrate

    Ornithine decarboxylase inhibitor.

    ≥98%
  • D3208

    Diclazuril

    Coccidiostat, GAPDH inhibitor.

    ≥98%
  • B9200

    BX-795

    PDK1 inhibitor.

    ≥98%
  • P2513

    Phenyl Isothiocyanate

    ITC found in cruciferous vegetables.

    ≥98%
  • F4503

    Flavokawain B

    Chalcone kavalactone that suppresses inflammation ...
    ≥97%
  • I7558

    1-Isothiocyanato-9-(methylsulfenyl)-nonane

    ITC, erucin analog.

    ≥97%
  • E7357

    Esomeprazole Potassium

    (S) isomer of omeprazole; H+/K+ ATPase and MAO-...

    ≥98%
  • D0032

    Daidzein

    Phytoestrogen, isoflavone found in various plan...

    ≥97%
  • D3355

    Diosgenin

    Steroidal saponin found in Dioscorea.

    ≥98%
  • F130280

    FHD-286

    BRG1/BRM ATPase inhibitor

    ≥98%
  • S3449

    Simvastatin

    Statin; HMG-CoA reductase inhibitor, potential ...

    ≥98%