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Dantrolene Sodium Heptahydrate

Dantrolene Sodium Heptahydrate

Product ID D0255
Cas No. 24868-20-0
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $110.60 In stock
250 mg $204.90 In stock
1 g $583.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Dantrolene is a hydantoin derivative that inhibits the ryanodine receptor (RyR), preventing mitochondrial Ca2+ uptake. Dantrolene also inhibits L-type Ca(V)1.1 Ca2+ channels and is clinically used to treat malignant hyperthermia. Dantrolene also exhibits cardioprotective activity, decreases apoptosis and TNF-α levels and increases IL-10 levels in various animal models of ischemia/reperfusion.

Product Info

Cas No.

24868-20-0

Purity

≥98%

Formula

(C14H9N4O5Na)2 • 7H2O

Formula Wt.

399.29

Chemical Name

1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione sodium

IUPAC Name

sodium;3-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-5-oxo-4H- imidazol-2-olate

Synonym

Dantamacrin, Dantrium, F-440, Dantrolene, Sodium Salt Hemiheptahydrate

Melting Point

279-280°C

Solubility

Slightly soluble in water; more soluble in alkaline soln.

Appearance

Yellowish-Orange to Orange Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D0255 MSDS PDF

Info Sheet

D0255 Info Sheet PDF

References

Jakob R, Beutner G, Sharma VK, et al. Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett. 2014 May 23. [Epub ahead of print]. PMID: 24861510.

Bannister RA. Dantrolene-induced inhibition of skeletal L-type Ca2+ current requires RyR1 expression. Biomed Res Int. 2013;2013:390493. PMID: 23509717.

Boys JA, Toledo AH, Anaya-Prado R, et al. Effects of dantrolene on ischemia-reperfusion injury in animal models: a review of outcomes in heart, brain, liver, and kidney. J Investig Med. 2010 Oct;58(7):875-82. PMID: 20517166.

Custom Order

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