Dasatinib Monohydrate

Name: Dasatinib Monohydrate
SKU: D0375
Availability: InStock

Product ID D0375

Cas No. 863127-77-9

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Dasatinib is an anticancer chemotherapeutic compound that inhibits Abl, PDGFR, ephrin receptors, Src, c-Kit, and other Src-family kinases (LCK, HCK, FYN, and others). Dasatinib is clinically used to treat chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL); in acute myelogenous leukemia (AML) cells, dasatinib induces myeloid differentiation and autophagy. Dasatinib also displays antiviral activity, preventing dengue virus infection through its inhibition of FYN kinase.

Product Info

Cas No.	863127-77-9
Purity	≥98%
Formula	C₂₂H₂₆ClN₇O₂S • H₂O
Formula Wt.	506.02
Chemical Name	N-(2-chlro-6-methylphenyl)-2-[[6-[4[(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide monohydrate
IUPAC Name	N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2- methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide;hydrate
Melting Point	280-286°C
Solubility	Sparingly soluble in water (5.06 mg/ml), and ethanol. Soluble in DMSO (200 mg/ml).
Appearance	White to Pale Yellow Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	D0375 MSDS PDF
Info Sheet	D0375 Info Sheet PDF

References

Xie N, Zhong L, Liu L, et al. Autophagy contributes to dasatinib-induced myeloid differentiation of human acute myeloid leukemia cells. Biochem Pharmacol. 2014 May 1;89(1):74-85. PMID: 24607273.

de Wispelaere M, LaCroix AJ, Yang PL. The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol. 2013 Jul;87(13):7367-81. PMID: 23616652.

Montero JC, Seoane S, Ocaña A, et al. Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. Clin Cancer Res. 2011 Sep 1;17(17):5546-52. PMID: 21670084.

Das J, Chen P, Norris D, et al. 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor. J Med Chem. 2006 Nov 16;49(23):6819-32. PMID: 17154512.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Comments
This field is for validation purposes and should be left unchanged.

Dasatinib Monohydrate

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Thiolutin

RGES

Neuromedin B, pig

GW-5074

Nobiletin

6-Mercaptopurine Monohydrate

CYT-387

Altertoxin 1

Histatin 5

Ginkgolide C

Rimantadine Hydrochloride

Leptomycin B

Anorexigenic Peptide

DCC-2036

Betamethasone 21-Phosphate Sodium

Loxoprofen Sodium Dihydrate

Bedaquiline Fumarate

Cyclocytidine Hydrochloride

Toremifene Base

Aminophylline Anhydrous

Footer