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Dehydroandrographolide is a labdane diterpene found in Andrographis that exhibits antiviral, antioxidative, and anti-inflammatory activities. In vitro, this compound inhibits hepatitis B virus replication. Additionally, dehydroandrographolide decreases LPS-induced expression of TNF-α, IL-1β, IL-6, and malondialdehyde and increases levels of superoxide dismutase in animal models of lung injury.
| Cas No. | 134418-28-3 |
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| Purity | ≥98% |
| Formula | C20H28O4 |
| Formula Wt. | 332.43 |
| IUPAC Name | (3E)-3-[2-[(1S,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]furan-2-one |
| Melting Point | 232-236°C |
| Solubility | Soluble in chloroform |
| Appearance | Off-White Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Chen H, Ma YB, Huang XY, et al. Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents. Bioorg Med Chem Lett. 2014 May 15;24(10):2353-9. PMID: 24731274.
Zhu T, Guan X, Zhang W, et al. Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1238-41. PMID: 22985554.