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Diclofenac Impurity B

Diclofenac Impurity B

Product ID D324096
Cas No. 22121-58-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $97.30 In stock
25 mg $227.10 In stock
100 mg $584.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Diclofenac Impurity B is an impurity of diclofenac.

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that is clinically used to treat inflammation associated with arthritis and gout as well as other pain or inflammatory disorders; it is somewhat selective in inhibiting COX-2 over COX-1. Diclofenac exhibits anti-inflammatory, antipyretic, analgesic, antinociceptive, anticonvulsant, anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. In vitro, the anticonvulsant/antiepileptic activity of diclofenac may stem from inhibition of delayed rectifier K+ channel amplitude and acceleration of channel inactivation; it also increases the amplitude of M-type K+ channels. This compound inhibits DMH-induced colon carcinogenesis in vivo, decreasing levels of COX-2, VEGF, and MCP-1. Diclofenac also decreases the epithelial-to-mesenchymal transition (EMT), suppressing squamous cell carcinoma tumor growth.

Product Info

Cas No.

22121-58-0

Purity

≥98%

Formula

C13H9Cl2NO

Formula Wt.

266.12

Chemical Name

2-[(2,6-Dichlorophenyl)amino]benzaldehyde

IUPAC Name

2-[(2,6-Dichlorophenyl)amino]benzaldehyde

Synonym

Diclofenac impurity 2, 2-(2,6-Dichloroanilino)benzaldehyde, 2-[(2,6-Dichlorophenyl)amino]benzaldehyde, N-(2,6-Dichlorophenyl)anthranilaldehyde, MFCD03788574

Melting Point

112-114°C

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D324096 MSDS PDF

Info Sheet

D324096 Info Sheet PDF

References

Giordano, F., Rossi, A., Pasquali, I. et al. Thermal degradation and melting point determination of diclofenac. Journal of Thermal Analysis and Calorimetry 73, 509–518 (2003). https://doi.org/10.1023/A:1025421911670

Arumugam A, Weng Z, Talwelkar SS, et al. Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis. PLoS One. 2013 Nov 8;8(11):e80076. PMID: 24260338.

Akbari E, Mirzaei E, Shahabi Majd N. Long-term Morphine-treated Rats are more Sensitive to Antinociceptive Effect of Diclofenac than the Morphine-naive rats. Iran J Pharm Res. 2013 Winter;12(1):175-84. PMID: 24250586.

Huang CW, Hung TY, Liao YK, et al. Underlying mechanism of regulatory actions of diclofenac, a nonsteroidal anti-inflammatory agent, on neuronal potassium channels and firing: an experimental and theoretical study. J Physiol Pharmacol. 2013 Jun;64(3):269-80. PMID: 23959723.

Kaur J, Sanyal SN. Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF. Mol Carcinog. 2011 Sep;50(9):707-18. PMID: 21268133.

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