LKT Labs

Biochemicals for Life Science Research

Disulfiram

Disulfiram

Product ID D3374
Cas No. 97-77-8
Purity ≥98%
Product Unit SizeCostQuantityStock
50 g $50.00 In stock
100 g $83.00 In stock
250 g $124.00 In stock
Bulk Quote

Quicklinks

Description

Disulfiram is an inhibitor of aldehyde dehydrogenase that is clinically used to treat chronic alcohol dependence. Disulfiram prevents complete metabolism of alcohol, allowing acetaldehyde to build up. Disulfiram also exhibits anticancer and anti-parasitic activities. This compound inhibits the 26S proteasome, activating caspases 3 and 7 and inducing apoptosis in chronic lymphocytic leukemia (CLL), non-small cell lung cancer (NSCLC), ovarian cancer, and breast cancer cells. Disulfiram also inhibits MGMT, potentially enhancing the efficacy of other co-administered chemotherapeutics. Additionally, disulfiram inhibits the growth of protozoans Trichomonas and Tritrichomonas.

Product Info

Cas No.

97-77-8
Purity

≥98%
Formula

C10H20N2S4
Formula Wt.

296.54
Chemical Name

Tetraethylthioperoxydicarbonic diamide
IUPAC Name

diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate
Synonym

Tetraethylthiuram disulfide, Teturamin, TTD, Cronetal, Abstensil, Antadix, Antietanol, Exhoran, Antabuse, Etabus, Esperal, Tetradine, Noxal, Tetraetil
Melting Point

70°C

Solubility

Soluble in alcohol (330 mg/mL), ether, acetone, benzene, or chloroform. Practically insoluble in water.

Appearance

Light yellow crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

D3374 MSDS PDF
Info Sheet

D3374 Info Sheet PDF

References

Paranjpe A, Zhang R, Ali-Osman F, et al. Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. PMID: 24193513.

Wickström M, Danielsson K, Rickardson L, et al. Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients. Biochem Pharmacol. 2007 Jan 1;73(1):25-33. PMID: 17026967.

Bouma MJ, Snowdon D, Fairlamb AH, et al. Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus. J Antimicrob Chemother. 1998 Dec;42(6):817-20. PMID: 10052908.

Wright C, Moore RD. Disulfiram treatment of alcoholism. Am J Med. 1990 Jun;88(6):647-55. Review. Erratum in: Am J Med 1991 Oct;91(4):446. PMID: 2189310.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • I5753

    Ionomycin Calcium

    Polyether Ca2+ ionophore.

    ≥98%
  • A480000

    AM251

    CB1 receptor antagonist/ inverse agonist.

    ≥97%
  • A0961

    Adrenocorticotropic Hormone (1-39), rat

    Endogenous peptide hormone, involved in stress ...

    ≥95%
  • O9396

    Oxytetracycline

    Tetracycline; protein translation inhibitor.

    ≥96%
  • B7973

    Busulfan

    Alkyl sulfonate; DNA alkylator.

    ≥98%
  • P9869

    Pyridoxine Hydrochloride

    Vitamin B6 derivative, antioxidant.

    ≥98%
  • T3033

    Thienyldodecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • T2834

    Thiolutin

    Dithiolopyrrolone; RNA polymerase inhibitor.

    ≥98%
  • L3374

    Lisinopril Dihydrate

    Enalapril analog; ACE inhibitor.

    ≥98%
  • P200600

    PF-06873600

    CDK2/4/6 inhibitor

    ≥98%
  • M5610

    Moclobemide

    MAO-A inhibitor.

    ≥98%
  • D4802

    17-Dimethylaminoethylamino Demethoxygeldanamycin

    Geldanamycin derivative; HSP90 inhibitor.

    ≥98%
  • N3208

    Nicardipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥99%
  • A0777

    ABT-263

    BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.

    ≥99%
  • O938565

    6-Oxodocetaxel

    Docetaxel impurity

    ≥98%
  • W0270

    (±)-Warfarin Sodium Clathrate

    Coumarin; VKORC1 inhibitor.

    ≥98%
  • M1749

    Memantine Hydrochloride

    D2 agonist, NMDA, 5-HT3, α7 nAChR antagonist.<...

    ≥97%
  • T0101

    7-epi-10-Deacetyltaxol

    Taxane found in Taxus; potential microtubule de...

    ≥98%
  • A4806

    Ambroxol Hydrochloride

    Expectorant.

    ≥98%
  • P7023

    Pregnenolone

    Endogenous precursor to all steroid hormones; T...

    ≥98%