Description
DpC (Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone) is a noval highly selective anti-tumor and anti-metastatic compound. It is highly effective against neuroblastoma cells.
DpC (Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone) is a noval highly selective anti-tumor and anti-metastatic compound. It is highly effective against neuroblastoma cells.
Cas No. | 1382469-39-7 |
---|---|
Purity | ≥99% |
Formula | C19H23N5S |
Formula Wt. | 353.5 |
Chemical Name | Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone |
IUPAC Name | 1-cyclohexyl-3-(dipyridin-2-ylmethylideneamino)-1-methylthiourea |
Synonym | N-Cyclohexyl-2-(di(pyridin-2-yl)methylene)-N-methylhydrazinecarbothioamide; DP4cych4mt; CHEMBL2203744; 6068Z4Y7QI |
Solubility | Insoluble in water. DMSO (~5 mg/mL). |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Sestak, V, Stariat, J1, Cermanova, J1, et al. Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents. Oncotarget. 2015; 6: 42411-42428. Retrieved from https://www.oncotarget.com/article/6389/text/
Guo, Z., Richardson, DR, Kalinowski, D. The novel thiosemicarbazone, di-2- pyridylketone 4-cyclohexyl-4-methyl-3- thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and
in vivo via multiple mechanisms. J Hemology & Oncology (2016) 9:98
β-lactam cephalosporin; penicillin binding pro...
Kavalactone originally found in Piper methystic...
Acyl transfer catalyst, involved in peptide syn...
Tropane alkaloid found in Solanaceae plants; mA...
β1-adrenergic antagonist.
Nucleoside (cytidine) analog; RT and telomerase...
DOT1L HMT inhibitor.
Bactericidal
Pyrimidine derivative; kinesin Eg5 inhibitor.
Fluoroquinolone; bacterial DNA gyrase inhibitor...
Triazole; demethylation inhibitor.
BHA derivative, cellular differentiation induce...
NSAID; COX-1/2 and lipoxygenase inhibitor.
pan-PI3K inhibitor.
5-Lipoxygenase inhibitor.
Steroid; glucocorticoid agonist.
Broad-spectrum antiviral activity against SARS-...
Saponin found in Polygala.
α3β2, α3β4, α4β2 nAChR antagonist, indire...
Pyrimidine nucleoside base, pairs with adenosin...