Description
DpC (Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone) is a noval highly selective anti-tumor and anti-metastatic compound. It is highly effective against neuroblastoma cells.
DpC (Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone) is a noval highly selective anti-tumor and anti-metastatic compound. It is highly effective against neuroblastoma cells.
Cas No. | 1382469-39-7 |
---|---|
Purity | ≥99% |
Formula | C19H23N5S |
Formula Wt. | 353.5 |
Chemical Name | Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone |
IUPAC Name | 1-cyclohexyl-3-(dipyridin-2-ylmethylideneamino)-1-methylthiourea |
Synonym | N-Cyclohexyl-2-(di(pyridin-2-yl)methylene)-N-methylhydrazinecarbothioamide; DP4cych4mt; CHEMBL2203744; 6068Z4Y7QI |
Solubility | Insoluble in water. DMSO (~5 mg/mL). |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Sestak, V, Stariat, J1, Cermanova, J1, et al. Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents. Oncotarget. 2015; 6: 42411-42428. Retrieved from https://www.oncotarget.com/article/6389/text/
Guo, Z., Richardson, DR, Kalinowski, D. The novel thiosemicarbazone, di-2- pyridylketone 4-cyclohexyl-4-methyl-3- thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and
in vivo via multiple mechanisms. J Hemology & Oncology (2016) 9:98
Thiazide diuretic; NCCT inhibitor, carbonic anh...
Glycosaminoglycan
Phenylpyrazoleanilide; IL-17 production inhibit...
GSK-3 inhibitor.
Endogenous peptide, involved in vascular contra...
Tropane alkaloid found in Solanaceae plants; mA...
Macrolide; threonyl-tRNA synthetase/ligase inhi...
Naturally occurring amino acid found in grains,...
Endogenous pyrimidine base required for product...
Endogenous steroid hormone involved in stress s...
Anthraquinone found in aloe; CTFR Cl- channel a...
Protonophore; chitinase OvCHT1 inhibitor.
PERK inhibitor.
Endogenous peptide hormone, involved in growth ...
Tropane alkaloid found in Solanaceae plants; M1...
Inhibitor of Monoacyglycerol lipase (MAGL).
Aurora kinase A inhibitor
Progesterone derivative; Cyp17A1 inhibitor.
Tyrphostin; IGF-1R inhibitor.
Peptide produced in tomato leaves; potential ca...