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Empagliflozin

Empagliflozin

Product ID E499601
Cas No. 864070-44-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $56.70 In stock
10 mg $78.80 In stock
50 mg $210.00 In stock
100 mg $341.30 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Empagliflozin is a sodium glucose cotransporter 2 inhibitor. Chronic treatment of Zucker diabetic fatty rats with empagliflozin was able to prevent the development of oxidative stress, AGE/RAGE signaling and inflammation, and to partially improve endothelial function. High-dose treatment of C57BL/6J mice with empagliflozin resulted in suppressed weight gain in addition to ameliorating glucose intolerance and insulin resistance. Empagliflozin treatment also protected mice from diet-induced hepatic steatosis and inflammation, decreased M1 macrophages, and increased M2 macrophages. Additionally, empagliflozin treatment lowered blood glucose levels, improved cardiac function, improved histopathalogic changes in the myocardium, and inhibited cardiomyocyte apoptosis by down-regulating expression of CHOP and GRP8 and inactivating caspase-12 in diabetic cardiomyopathy rats.

Product Info

Cas No.

864070-44-0

Purity

≥98%

Formula

C23H27ClO7

Formula Wt.

450.91

Chemical Name

(2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol

IUPAC Name

(1S)-1,5-Anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydro-3-furanyloxy]benzyl}phenyl)-D-glucitol

Synonym

Jardiance

Solubility

30mg/mL in organic solvents such as ethanol, DMSO, and dimethyl formamide. Sparingly soluble in aqueous buffers.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Blue Ice

Downloads

MSDS

E499601 MSDS PDF

Info Sheet

E499601 Info Sheet PDF

References

Steven S, Oelze M, Hanf A, et al. The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats. Redox Biol. 2017 Oct;13:370-385. PMID: 28667906.

Xu L, Nagata N, Nagashimada M, et al. SGLT2 inhibition by empagliflozin promotes fat utilization and browning and attenuates inflammation and insulin resistance by polarizing M2 macrophages in diet-induced obese mice. EBioMedicine. 2017 Jun;20:137-149. PMID: 28579299.

Zhou Y, Wu W. The sodium-glucose co-transporter 2 inhibitor, empagliflozin, protects against diabetic cardiomyopathy by inhibition of the endoplasmic reticulum stress pathway. Cell Physiol Biochem. 2017;41(6):2503-2512. PMID: 28472796.

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