• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Empagliflozin

Empagliflozin

Product ID E499601
Cas No. 864070-44-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $56.70 In stock
10 mg $78.80 In stock
50 mg $210.00 In stock
100 mg $341.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Empagliflozin is a sodium glucose cotransporter 2 inhibitor. Chronic treatment of Zucker diabetic fatty rats with empagliflozin was able to prevent the development of oxidative stress, AGE/RAGE signaling and inflammation, and to partially improve endothelial function. High-dose treatment of C57BL/6J mice with empagliflozin resulted in suppressed weight gain in addition to ameliorating glucose intolerance and insulin resistance. Empagliflozin treatment also protected mice from diet-induced hepatic steatosis and inflammation, decreased M1 macrophages, and increased M2 macrophages. Additionally, empagliflozin treatment lowered blood glucose levels, improved cardiac function, improved histopathalogic changes in the myocardium, and inhibited cardiomyocyte apoptosis by down-regulating expression of CHOP and GRP8 and inactivating caspase-12 in diabetic cardiomyopathy rats.

Product Info

Cas No.

864070-44-0

Purity

≥98%

Formula

C23H27ClO7

Formula Wt.

450.91

Chemical Name

(2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol

IUPAC Name

(1S)-1,5-Anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydro-3-furanyloxy]benzyl}phenyl)-D-glucitol

Synonym

Jardiance

Solubility

30mg/mL in organic solvents such as ethanol, DMSO, and dimethyl formamide. Sparingly soluble in aqueous buffers.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Blue Ice

Downloads

MSDS

E499601 MSDS PDF

Info Sheet

E499601 Info Sheet PDF

References

Steven S, Oelze M, Hanf A, et al. The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats. Redox Biol. 2017 Oct;13:370-385. PMID: 28667906.

Xu L, Nagata N, Nagashimada M, et al. SGLT2 inhibition by empagliflozin promotes fat utilization and browning and attenuates inflammation and insulin resistance by polarizing M2 macrophages in diet-induced obese mice. EBioMedicine. 2017 Jun;20:137-149. PMID: 28579299.

Zhou Y, Wu W. The sodium-glucose co-transporter 2 inhibitor, empagliflozin, protects against diabetic cardiomyopathy by inhibition of the endoplasmic reticulum stress pathway. Cell Physiol Biochem. 2017;41(6):2503-2512. PMID: 28472796.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R3312

    Ridaifen A Dihydrochloride

    Tamoxifen derivative; potential proteasome inhi...

    ≥98%
  • S0170

    Sarafloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥95%
  • V3476

    Vitamin D2

    Vitamin D prodrug produced by fungi and alfalfa...

    ≥91%
  • L1817

    Leflunomide

    AhR agonist, dihydroorotate dehydrogenase inhib...

    ≥98%
  • B3374

    Bisacodyl

    Diphenylmethane derivative, stimulates colonic ...

    ≥98%
  • C6956

    Crotamiton

    Antipruritic.  
    ≥98%
  • T1656

    Tenoxicam Impurity B

    Tenoxicam impurity

    ≥98%
  • O9210

    Oxcarbazepine

    α4β2 nAChR desensitizer, delayed-rectifier vo...

    ≥98%
  • A9712

    AZD-6482

    p110β PI3K inhibitor.

    ≥98%
  • M0273

    Mastoparan 8

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • P4780

    Plumbagin

    Naphthoquinone found in Plumbago.

    ≥98%
  • D1621

    Deferasirox

    Iron chelator.

    ≥99%
  • S336507

    Simufilam Dihydrochloride

    Unlikely to reverse Alzheimer’s

    ≥98%
  • B8144

    Bulleyaconitine A

    Found in Aconitum bulleyanum; voltage-gated Na+...

    ≥95%
  • E7857

    Etofenamate

    NSAID; COX-1/2 and lipoxygenase inhibitor.

    ≥98%
  • A5277

    Angiotensin II, human

    Endogenous peptide, involved in vasoconstrictio...

    ≥95%
  • G0179

    Gastrin-1, rat

    Endogenous peptide hormone; CCK2 agonist, indir...

    ≥95%
  • M9367

    Myricetin

    Flavonol found in fruits and vegetables; COMT i...

    ≥98%
  • N8561

    NVP-AEW541

    IGF-1R inhibitor.

    ≥98%
  • A7658

    Atorvastatin Calcium Trihydrate

    Statin; HMG-CoA reductase inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only