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Endothelin-1, human

Endothelin-1, human

Product ID E5219
Cas No. 117399-94-7
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $204.40 In stock
1 mg $272.60 In stock
2.5 mg $613.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Endothelin-1 is an endogenous peptide agonist at endothelin A and B (ET-A/B) receptors that exhibits anti-angiogenic and vasoconstrictive activities. Endothelin-1 decreases tube formation and PPARγ expression in pulmonary artery endothelial cells. This peptide also increases expression of IL-18 in osteoblasts, inducing proliferation.

Product Info

Cas No.

117399-94-7

Purity

≥95%

Formula

C109H159N25O32S5

Formula Wt.

2491.95

Synonym

ET-1.

Solubility

Soluble in 1% acetic acid (1 mg/mL), water (1 mg/mL), 50% acetonitrile (1 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E5219 MSDS PDF

Info Sheet

E5219 Info Sheet PDF

References

Zhong X, Wang H, Huang S. Endothelin-1 induces interleukin-18 expression in human osteoblasts. Arch Oral Biol. 2014 Mar;59(3):289-96. PMID: 24581851.

Osmond JM, Gonzalez Bosc LV, Walker BR, et al. Endothelin-1-induced vasoconstriction does not require intracellular Ca2+ waves in arteries from rats exposed to intermittent hypoxia. Am J Physiol Heart Circ Physiol. 2014 Mar;306(5):H667-73. PMID: 24414066.

Wolf D, Tseng N, Seedorf G, et al. Endothelin-1 decreases endothelial PPARγ signaling and impairs angiogenesis after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(4):L361-71. PMID: 24337925.

Custom Order

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