• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Esculetin

Esculetin

Product ID E7309
Cas No. 305-01-1
Purity ≥99%
Product Unit SizeCostQuantityStock
500 mg $75.60 In stock
1 g $127.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Esculetin is a coumarin lactone found in chicory and other plants; it exhibits anticoagulant, anti-obesity, anti-hyperlipidemic, anti-inflammatory, anticancer, antioxidative, and neuroprotective activities. Esculetin decreases levels of NO, PPARγ, TNF-α, and MCP-1 and increases levels of heme oxygenase 1 (HO-1) in macrophages. In animal models of Parkinson’s disease, esculetin inhibits MPTP-induced neurotoxicity and neuronal apoptosis. In high fat diet-fed rats, this compound decreases body weight, triglyceride levels, total cholesterol, and glucose levels. Additionally, esculetin induces cell cycle arrest, DNA fragmentation, activation of caspases 3 and 9, reduction of the mitochondrial membrane potential, and apoptosis in acute promyelocytic leukemia (APL) cells. Esculetin also inhibits proliferation of colon cancer cells by directly inhibiting β-catenin. This compound also acts as a radical scavenger in vitro.

Product Info

Cas No.

305-01-1

Purity

≥99%

Formula

C9H6O4

Formula Wt.

178.14

Chemical Name

6,7-Dihydroxy-2H-1-benzopyran-2-one

IUPAC Name

6,7-dihydroxychromen-2-one

Synonym

6,7-Dihydroxycoumarin, Cichorigenin

Melting Point

268-270°C

Solubility

Soluble in dil alkalies, hot alcohol or glacial acetic acid. Insoluble in ether or boiling water.

Appearance

Light Yellow Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E7309 MSDS PDF

Info Sheet

E7309 Info Sheet PDF

Brochures

WNT Booklet

References

Kim Y, Park Y, Namkoong S, et al. Esculetin inhibits the inflammatory response by inducing heme oxygenase-1 in cocultured macrophages and adipocytes. Food Funct. 2014 Aug 20;5(9):2371-7. PMID: 25088305.

Rubio V, Calviño E, García-Pérez A, et al. Human acute promyelocytic leukemia NB4 cells are sensitive to esculetin through induction of an apoptotic mechanism. Chem Biol Interact. 2014 Jul 1;220C:129-139. PMID: 24995577.

Medina ME, Galano A, Alvarez-Idaboy JR. Theoretical study on the peroxyl radicals scavenging activity of esculetin and its regeneration in aqueous solution. Phys Chem Chem Phys. 2014 Jan 21;16(3):1197-207. PMID: 24292723.

Lee SY, Lim TG, Chen H, et al. Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin. Cancer Prev Res (Phila). 2013 Dec;6(12):1356-64. PMID: 24104353.

Karmase A, Birari R, Bhutani KK. Evaluation of anti-obesity effect of Aegle marmelos leaves. Phytomedicine. 2013 Jul 15;20(10):805-12. PMID: 23632084.

Subramaniam SR, Ellis EM. Neuroprotective effects of umbelliferone and esculetin in a mouse model of Parkinson's disease. J Neurosci Res. 2013 Mar;91(3):453-61. PMID: 23184853.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C4646

    Clofarabine

    Nucleoside (adenosine) analog; DNA chain termin...

    ≥98%
  • T0205

    3”,4”-Dehydropaclitaxel C

    Semi-synthetic taxane.

    ≥95%
  • B8074

    3-tert-Butyl-5-Methoxy-1,2-quinone

    BHA derivative.

    ≥98%
  • A5234

    Amisulpride

    5-HT7 and D2/3 antagonist.

    ≥98%
  • I7457

    1-Isothiocyanato-6-(methylsulfinyl)-hexane

    Synthetic derivative of 6-methylsulfinyl-hexane...

    ≥98%
  • R2812

    Recombinant HIV-1 gp-120

    Recombinant HIV glycoprotein antigen fragment.<...

    ≥95%
  • A6925

    L-Arginine Ethyl Ester Dihydrochloride

    Arginine source used to increase NO production....

    ≥98%
  • S9753

    Synephrine

    Endogenous alkaloid also found in citrus fruits...

    ≥98%
  • C6955

    Cromolyn Sodium

    Mast cell destabilizer; potential TRP antagonis...

    ≥99%
  • A4438

    Allatostatin I

    Neuropeptide found in insects; juvenile hormone...

    ≥95%
  • H965143

    Hydrolyzed Fumonisin B2

    Mycotoxin produced by Fusarium fungi that infec...

    ≥97% by ELSD
  • W7201

    WS6

    Islet α/β cell proliferation stimulator.

    ≥98%
  • M5752

    Monastrol

    Pyrimidine derivative; kinesin Eg5 inhibitor.

    ≥95%
  • A4933

    Amifostine Trihydrate

    Thiol prodrug, antioxidant.

    ≥98%
  • I4802

    Imatinib Mesylate

    Abl, c-Kit, PDGFR inhibitor.

    ≥98%
  • B1603

    Beauvericin

    Cyclic hexadepsipeptide mycotoxin produced by C...

    ≥95%
  • A4931

    3-Aminobenzamide

    PARP inhibitor.

    ≥97%
  • N8662

    NVP-BGJ398

    FGFR inhibitor.

    ≥98%
  • A5217

    trans-Anethole

    Phenylpropene derivative found in essential oil...

    ≥98%
  • M5746

    Molsidomine

    NO donor; annexin A2 inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only