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Esculetin

Esculetin

Product ID E7309
Cas No. 305-01-1
Purity ≥99%
Product Unit SizeCostQuantityStock
500 mg $75.60 In stock
1 g $127.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Esculetin is a coumarin lactone found in chicory and other plants; it exhibits anticoagulant, anti-obesity, anti-hyperlipidemic, anti-inflammatory, anticancer, antioxidative, and neuroprotective activities. Esculetin decreases levels of NO, PPARγ, TNF-α, and MCP-1 and increases levels of heme oxygenase 1 (HO-1) in macrophages. In animal models of Parkinson’s disease, esculetin inhibits MPTP-induced neurotoxicity and neuronal apoptosis. In high fat diet-fed rats, this compound decreases body weight, triglyceride levels, total cholesterol, and glucose levels. Additionally, esculetin induces cell cycle arrest, DNA fragmentation, activation of caspases 3 and 9, reduction of the mitochondrial membrane potential, and apoptosis in acute promyelocytic leukemia (APL) cells. Esculetin also inhibits proliferation of colon cancer cells by directly inhibiting β-catenin. This compound also acts as a radical scavenger in vitro.

Product Info

Cas No.

305-01-1

Purity

≥99%

Formula

C9H6O4

Formula Wt.

178.14

Chemical Name

6,7-Dihydroxy-2H-1-benzopyran-2-one

IUPAC Name

6,7-dihydroxychromen-2-one

Synonym

6,7-Dihydroxycoumarin, Cichorigenin

Melting Point

268-270°C

Solubility

Soluble in dil alkalies, hot alcohol or glacial acetic acid. Insoluble in ether or boiling water.

Appearance

Light Yellow Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E7309 MSDS PDF

Info Sheet

E7309 Info Sheet PDF

Brochures

WNT Booklet

References

Kim Y, Park Y, Namkoong S, et al. Esculetin inhibits the inflammatory response by inducing heme oxygenase-1 in cocultured macrophages and adipocytes. Food Funct. 2014 Aug 20;5(9):2371-7. PMID: 25088305.

Rubio V, Calviño E, García-Pérez A, et al. Human acute promyelocytic leukemia NB4 cells are sensitive to esculetin through induction of an apoptotic mechanism. Chem Biol Interact. 2014 Jul 1;220C:129-139. PMID: 24995577.

Medina ME, Galano A, Alvarez-Idaboy JR. Theoretical study on the peroxyl radicals scavenging activity of esculetin and its regeneration in aqueous solution. Phys Chem Chem Phys. 2014 Jan 21;16(3):1197-207. PMID: 24292723.

Lee SY, Lim TG, Chen H, et al. Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin. Cancer Prev Res (Phila). 2013 Dec;6(12):1356-64. PMID: 24104353.

Karmase A, Birari R, Bhutani KK. Evaluation of anti-obesity effect of Aegle marmelos leaves. Phytomedicine. 2013 Jul 15;20(10):805-12. PMID: 23632084.

Subramaniam SR, Ellis EM. Neuroprotective effects of umbelliferone and esculetin in a mouse model of Parkinson's disease. J Neurosci Res. 2013 Mar;91(3):453-61. PMID: 23184853.

Custom Order

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