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FLI-06

Product ID F4432
Cas No. 313967-18-9
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $54.00 In stock
5 mg $86.40 In stock
25 mg $324.00 In stock
50 mg $540.00 In stock
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  • Description
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Description

FLI-06 is a dihydropyridine inhibitor of γ-secretase that suppresses Notch signaling in vitro and in vivo. FLI-06 inhibits protein secretion prior to endoplasmic reticulum exit. Like other Notch signaling inhibitors, FLI-06 likely displays neuroprotective activity.

Product Info

Cas No.

313967-18-9

Purity

≥99%

Formula

C25H30N2O5

Formula Wt.

438.52

Chemical Name

1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester

IUPAC Name

Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate

Synonym

FLI 06, FLI06

Solubility

DMSO 88 mg/mL (200.67 mM) Ethanol 8 mg/mL (18.24 mM) Water Insoluble

Appearance

Yellow crystal powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

F4432 MSDS PDF

Info Sheet

F4432 Info Sheet PDF

References

Krämer A, Mentrup T, Kleizen B, et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat Chem Biol. 2013 Nov;9(11):731-8. PMID: 24077179.

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