Name: FLI-06
SKU: F4432
Availability: InStock

Description

FLI-06 is a dihydropyridine inhibitor of γ-secretase that suppresses Notch signaling in vitro and in vivo. FLI-06 inhibits protein secretion prior to endoplasmic reticulum exit. Like other Notch signaling inhibitors, FLI-06 likely displays neuroprotective activity.

Product Info

Cas No.	313967-18-9
Purity	≥99%
Formula	C₂₅H₃₀N₂O₅
Formula Wt.	438.52
Chemical Name	1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester
IUPAC Name	Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate
Synonym	FLI 06, FLI06
Solubility	DMSO 88 mg/mL (200.67 mM) Ethanol 8 mg/mL (18.24 mM) Water Insoluble
Appearance	Yellow crystal powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	F4432 MSDS PDF
Info Sheet	F4432 Info Sheet PDF

References

Krämer A, Mentrup T, Kleizen B, et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat Chem Biol. 2013 Nov;9(11):731-8. PMID: 24077179.

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FLI-06

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