LKT Labs

Biochemicals for Life Science Research

Gallocatechin Gallate

Product ID G0245
Cas No. 4233-96-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $82.70 In stock
5 mg $176.60 In stock
10 mg $280.90 In stock
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Description

Gallocatechin galleate (GCG) is a polyphenol originally derived from a variety of sources, including green tea, coffee, safflower, and almonds. GCG exhibits a wide variety of beneficial properties, including anti-diabetic, anti-osteoporotic, antiviral, anti-parasitic, and anticancer chemotherapeutic activities. GCG inhibits amyloid formation by islet amyloid polypeptide (amylin) and also inhibits glutathione-S-transferase in cellular models. GCG inhibits HIV integrase, preventing its ability to bind to DNA. Separately, this compound prevents hatching of nematodes in vivo. GCG also has positive effects on bone metabolism, decreasing osteoclastogenesis and inhibiting osteoclast differentiation.

Product Info

Cas No.

4233-96-9
Purity

≥98%
Formula

C22H18O11
Formula Wt.

458.37
IUPAC Name

[(2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3, 4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

G0245 MSDS PDF
Info Sheet

G0245 Info Sheet PDF
Brochures

Green Tea Flyer

Natural Products Flyer

References

Masler EP. Effects of catechin polyphenols and preparations from the plant-parasitic nematode Heterodera glycines on protease activity and behaviour in three nematode species. J Helminthol. 2013 May 2:1-8. [Epub ahead of print]. PMID: 23635519.

Timmel MA, Byl JA, Osheroff N. Epimerization of Green Tea Catechins during Brewing Does Not Affect the Ability to Poison Human Type II Topoisomerases. Chem Res Toxicol. 2013 Apr 4. [Epub ahead of print]. PMID: 23514406.

Boušová I, Hájek J, Dršata J, et al. Naturally occurring flavonoids as inhibitors of purified cytosolic glutathione S-transferase. Xenobiotica. 2012 Sep;42(9):872-9. PMID: 22458346.

Cao P, Raleigh DP. Analysis of the inhibition and remodeling of islet amyloid polypeptide amyloid fibers by flavanols. Biochemistry. 2012 Apr 3;51(13):2670-83. PMID: 22409724.

Jiang F, Chen W, Yi K, et al. The evaluation of catechins that contain a galloyl moiety as potential HIV-1 integrase inhibitors. Clin Immunol. 2010 Dec;137(3):347-56. PMID: 20832370.

Ko CH, Lau KM, Choy WY, et al. Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. J Agric Food Chem. 2009 Aug 26;57(16):7293-7. PMID: 19653629.

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