(-)-Gambogic Acid

Name: (-)-Gambogic Acid
SKU: G0248
Availability: InStock

Product ID G0248

Cas No. 2752-65-0

Purity ≥99%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

(-)-Gambogic acid is a xanthone found in the resin of the Garcinia hanburyi tree and has shown considerable anticancer chemotherapeutic, chemopreventive, and anti-angiogenic activities in both in vitro and in vivo studies. Gambogic acid inhibits cellular growth and induces apoptosis through a variety of mechanisms. This compound induces LRIG1 upregulation and EGFR degradation to inactivate Akt signaling. Additionally, gambogic acid also inhibits NF-κB signaling through interaction with the transferrin receptor, causing reduction of c-MYC expression, inhibition of telomerase activity and mRNA production, and disruption of mitochondrial outer membrane potential.

Product Info

Cas No.	2752-65-0
Purity	≥99%
Formula	C₃₈H₄₄O₈
Formula Wt.	628.75
Chemical Name	(Z)-4-[(1S,2S,8R,17S,19R)-12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enoic acid
IUPAC Name	(Z)-4-[(1S,2S,8R,17S,19R)-12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enoic acid
Synonym	beta-Guttiferrin, Cambogic acid, R-gambogic acid, Guttic acid, Guttatic acid, beta-Guttilactone, gambogoic acid
Melting Point	97.5°C
Solubility	Insoluble in water, soluble in DMSO (25 mg/mL), and ethanol (25 mg/mL).
Appearance	Yellow-orange solid

Shipping and Storage

Store Temp	-20°C
Ship Temp	ambient

Downloads

MSDS	G0248 MSDS PDF
Info Sheet	G0248 Info Sheet PDF

References

He XY, Liu XJ, Chen X, et al. Gambogic acid induces EGFR degradation and Akt/mTORC1 inhibition through AMPK dependent-LRIG1 upregulation in cultured U87 glioma cells. Biochem Biophys Res Commun. 2013 Jun 7;435(3):397-402. PMID: 23665322.

Gu H, Rao S, Zhao J, et al. Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells. J Cancer Res Clin Oncol. 2009 Dec;135(12):1777-82. PMID: 19582475.

Nie F, Zhang X, Qi Q, et al. Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells. Toxicology. 2009 Jun 16;260(1-3):60-7. PMID: 19464570.

Pandey MK, Sung B, Ahn KS, et al. Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway. Blood. 2007 Nov 15;110(10):3517-25. PMID: 17673602.

Wu ZQ, Guo QL, You QD, et al. Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells. Biol Pharm Bull. 2004 Nov;27(11):1769-74. PMID: 15516720.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

(-)-Gambogic Acid

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Aflatoxin M2

CEP-37440 Hydrochloride

Bergenin

Corosolic Acid

Topotecan Hydrochloride

Diclofenac Impurity B

Amylin (8-37), rat

D-Luciferin Potassium

JW55

Ecdysterone

Grapiprant

S-(−)-Warfarin Sodium >99%ee

Rabeprazole Sodium

Fludarabine Phosphate

AP-26113

Thymus Factor

Flutriafol

Desmopressin Acetate

Terpinen-4-ol

Entecavir

Footer