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GBR 12935 Dihydrochloride

GBR 12935 Dihydrochloride

Product ID G0668
Cas No. 67469-81-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $67.60 In stock
25 mg $228.10 In stock
100 mg $810.20 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GBR 12935 is an inhibitor of the dopamine transporter (DAT) that increases activation of DA receptors and is used to study DA signaling. This compound increases reward and reinforcement signaling, mimicking the activation of D1 and D2 receptors and increases in glutamate levels that occur during chronic administration of abused substances such as cocaine.

Product Info

Cas No.

67469-81-2

Purity

≥98%

Formula

C28H34N2O • 2HCl

Formula Wt.

487.51

IUPAC Name

1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride

Solubility

DMSO: 20 mg/mL

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G0668 MSDS PDF

Info Sheet

G0668 Info Sheet PDF

References

Root DH, Hoffman AF, Good CH, et al. Norepinephrine activates dopamine D4 receptors in the rat lateral habenula. J Neurosci. 2015 Feb 25;35(8):3460-9. PMID: 25716845.

Zuo W, Chen L, Wang L, et al. Cocaine facilitates glutamatergic transmission and activates lateral habenular neurons. Neuropharmacology. 2013 Jul;70:180-9. PMID: 23347950.

Janowsky A, Berger P, Vocci F, et al. Characterization of sodium-dependent [3H]GBR-12935 binding in brain: a radioligand for selective labelling of the dopamine transport complex. J Neurochem. 1986 Apr;46(4):1272-6. PMID: 3081686.

Custom Order

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